I. G. L. Pauli

TL;DR: The present data identify Furin as an important activator of signals responsible for ventral closure and embryonic turning as well as cardiac and endodermal marker genes that are compromised.

TL;DR: The generation and characterization of an interferon inducible Mx-Cre/loxP furin knock-out mouse model is reported and the absence of a severe phenotype raises the possibility of using furin as a local therapeutic target in the treatment of pathologies like cancer and viral infections.

TL;DR: It is shown that Dfur2 encodes an endoproteolytic enzyme with specificity for paired basic amino acid residues as, in cotransfection experiments, correct cleavage was demonstrated of the precursor of the von Willebrand factor but not of a cleavage mutant.

TL;DR: From overlapping Dfur1 cDNA clones, a composite cDNA could be constructed and analysis of its nucleotide sequence revealed the coding sequence for a protein of 899 amino acid residues that exhibited striking sequence homology to human furin and contained the same protein domains except for the cysteine‐rich region.

TL;DR: The studies indicate that the Dfur1 gene encodes structurally different subtilisin‐like proprotein processing enzymes with distinct physiological functions in Drosophila.