Dieter Hartmann

TL;DR: This comprehensive evaluation of EG FR ligand shedding in a defined experimental system demonstrates that ADAMs have critical roles in releasing all EGFR ligands tested here, and has implications for designing novel inhibitors of EGFR-dependent tumors.

TL;DR: Findings indicate that LAMP-2 is critical for autophagy, and this theory is further substantiated by the finding that human Lamp-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes.

TL;DR: Results indicate that either a regulation between ADAMs on the post-translational level or that other, not yet known, proteases are able to compensate for ADAM 10 deficiency, and points to the existence of tissue-specific 'teams' of different proteases exerting alpha-secretase activity.

TL;DR: Findings implicate regulated intramembrane proteolysis in controlling apoptosis in Parl-/- mice, substantiating the importance of PARL in OPA1 processing.

TL;DR: It is demonstrated here that neuronal cadherin (N‐cadherin) is cleaved specifically by the disintegrin and metalloproteinase ADAM10 in its ectodomain, leading to the conclusion that this protease constitutes a central switch in the signalling pathway from N‐cADherin at the cell surface to β‐catenin/LEF‐1‐regulated gene expression in the nucleus.