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Anton J.M. Roebroek
Researcher at Katholieke Universiteit Leuven
Publications - 46
Citations - 2910
Anton J.M. Roebroek is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Furin & LRP1. The author has an hindex of 28, co-authored 45 publications receiving 2609 citations.
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Journal ArticleDOI
A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death.
Abhishek D. Garg,Dmitri V. Krysko,Tom Verfaillie,Agnieszka Kaczmarek,Gabriela B Ferreira,Thierry Marysael,N Rubio,Malgorzata Firczuk,Malgorzata Firczuk,Chantal Mathieu,Anton J.M. Roebroek,Wim Annaert,Jakub Golab,Jakub Golab,Peter de Witte,Peter Vandenabeele,Patrizia Agostinis +16 more
TL;DR: A novel PERK‐dependent subroutine for the early and simultaneous emission of two critical DAMPs following ROS‐mediated ER stress is unraveled.
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Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
Diana Ines Dominguez,Jos Tournoy,Dieter Hartmann,Tobias Huth,Kim Cryns,Siska Deforce,Lutgarde Serneels,Ira Mercedes Espuny Camacho,Els Marjaux,Katleen Craessaerts,Anton J.M. Roebroek,Michael Schwake,Rudi D'Hooge,Patricia Bach,Ulrich Kalinke,Dieder Moechars,Christian Alzheimer,Karina Reiss,Paul Saftig,Bart De Strooper +19 more
TL;DR: The data indicate that BACE2 could indeed contribute to Aβ generation in the brains of Alzheimer disease and, in particular, Down syndrome patients and call for some caution when claiming that no major side effects should be expected from blocking BACE1 activity.
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T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Marko Pesu,Wendy T. Watford,Lai Wei,Lili Xu,Ivan J. Fuss,Warren Strober,John Andersson,Ethan M. Shevach,Martha Quezado,Nicolas Bouladoux,Anton J.M. Roebroek,Yasmine Belkaid,John W.M. Creemers,John J. O'Shea +13 more
TL;DR: The results suggest that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance, which is due, at least in part, to its non-redundant, essential function in regulating TGF-β1 production.
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Limited Redundancy of the Proprotein Convertase Furin in Mouse Liver
Anton J.M. Roebroek,Neil A. Taylor,Els Louagie,I. G. L. Pauli,Liesbeth Smeijers,An Snellinx,Annick Lauwers,Wim J.M. Van de Ven,Dieter Hartmann,John W.M. Creemers +9 more
TL;DR: The generation and characterization of an interferon inducible Mx-Cre/loxP furin knock-out mouse model is reported and the absence of a severe phenotype raises the possibility of using furin as a local therapeutic target in the treatment of pathologies like cancer and viral infections.
Journal ArticleDOI
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum.
John W.M. Creemers,Martin Vey,Wolfram Schäfer,Torik A.Y. Ayoubi,Anton J.M. Roebroek,Hans-Dieter Klenk,Wolfgang Garten,Wim J.M. Van de Ven +7 more
TL;DR: Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.