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I-Huan Wu
Researcher at University of Massachusetts Medical School
Publications - 5
Citations - 5502
I-Huan Wu is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Mitogen-activated protein kinase kinase & MAPKAPK2. The author has an hindex of 4, co-authored 5 publications receiving 5433 citations. Previous affiliations of I-Huan Wu include University of California, San Diego.
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JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Benoit Dérijard,Benoit Dérijard,Masahiko Hibi,I-Huan Wu,I-Huan Wu,Tamera Barrett,Bing Su,Tiliang Deng,Michael Karin,Roger J. Davis,Roger J. Davis +10 more
TL;DR: JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation and its properties indicate that JNK1 activation may play an important role in tumor promotion.
Journal ArticleDOI
Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
Benoit Dérijard,Joel Raingeaud,Tamera Barrett,I-Huan Wu,Jiahuai Han,Richard J. Ulevitch,Roger J. Davis +6 more
TL;DR: It is demonstrated that the activators of p38, MKK3 and MKK4, JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.
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An Osmosensing Signal Transduction Pathway in Mammalian Cells
TL;DR: Data indicate that related protein kinases may mediate osmosensing signal transduction in yeast and mammalian cells.
Journal ArticleDOI
Binding of Zinc Finger Protein ZPR1 to the Epidermal Growth Factor Receptor
Zoya Galcheva-Gargova,Konstantin N. Konstantinov,I-Huan Wu,F. George Klier,Tamera Barrett,Roger J. Davis +5 more
TL;DR: Deletion analysis demonstrated that this binding interaction is mediated by the zinc fingers of ZPR1 and subdomains X and XI of the EGFR tyrosine kinase, representing a prototype for a class of molecule that binds to the EG FR and is released from the receptor after activation.
Immunity Gene Expression Drosophila Kinase Pathway Regulates A Conserved p38 Mitogen-Activated Protein
I-Huan Wu,Tamera Barrett,Roger J. Davis,Y. Tony,Stanley Han,Hervé Enslen,Xiaodi Hu,Xiangjun Meng +7 more
TL;DR: This work has investigated the possible involvement of the p38 MAP kinase pathway in the mechanism that leads to the phosphorylation of p38mitogen-activated protein (MAP) kinase on Thr and Tyr within the motif Thr-Gly-Tyr, which is located withubdomain VIII.