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Benoit Dérijard
Researcher at University of Nice Sophia Antipolis
Publications - 35
Citations - 14744
Benoit Dérijard is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Mitogen-activated protein kinase & Signal transduction. The author has an hindex of 24, co-authored 35 publications receiving 14509 citations. Previous affiliations of Benoit Dérijard include University of California, San Diego & University of Massachusetts Medical School.
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Journal ArticleDOI
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Benoit Dérijard,Benoit Dérijard,Masahiko Hibi,I-Huan Wu,I-Huan Wu,Tamera Barrett,Bing Su,Tiliang Deng,Michael Karin,Roger J. Davis,Roger J. Davis +10 more
TL;DR: JNK1 is a component of a novel signal transduction pathway that is activated by oncoproteins and UV irradiation and its properties indicate that JNK1 activation may play an important role in tumor promotion.
Journal ArticleDOI
Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
Benoit Dérijard,Joel Raingeaud,Tamera Barrett,I-Huan Wu,Jiahuai Han,Richard J. Ulevitch,Roger J. Davis +6 more
TL;DR: It is demonstrated that the activators of p38, MKK3 and MKK4, JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.
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Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
TL;DR: A role for the JNK signal transduction pathway in transcriptional responses mediated by ATF2 is demonstrated and mutations in this pathway inhibited ATF2-stimulated gene expression mediated by the retinoblastoma tumor suppressor and the adenovirus early region 1A (E1A) oncoprotein.
Journal ArticleDOI
Selective interaction of JNK protein kinase isoforms with transcription factors.
Shashi Gupta,Tamera Barrett,Alan J. Whitmarsh,Julie Cavanagh,Hayla Karen Sluss,Benoit Dérijard,Roger J. Davis +6 more
TL;DR: Comparison of the binding activity of the JNK isoforms demonstrated that the J NK proteins differ in their interaction with ATF2, Elk‐1 and Jun transcription factors, suggesting that individual members of theJNK group may selectively target specific transcription factors in vivo.
Journal ArticleDOI
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
TL;DR: Cotransfection experiments demonstrated that p38 MAP kinase activation causes increased reporter gene expression mediated by the transcription factors ATF2 and Elk-1, demonstrating that the nucleus is one target of the p38MAP kinase signal transduction pathway.