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I-Shan Chen
Researcher at National Institutes of Natural Sciences, Japan
Publications - 15
Citations - 198
I-Shan Chen is an academic researcher from National Institutes of Natural Sciences, Japan. The author has contributed to research in topics: G protein-coupled inwardly-rectifying potassium channel & Chemistry. The author has an hindex of 7, co-authored 11 publications receiving 132 citations. Previous affiliations of I-Shan Chen include Wakayama Medical University & Graduate University for Advanced Studies.
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Journal ArticleDOI
Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.
TL;DR: An update and summary of recent progress in the identification of IVM targets, as well as their modulation mechanisms, through molecular structures, chimeras and site‐directed mutagenesis, and molecular docking and modelling studies is provided.
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Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7.
Jun Ishii,Atsushi Suzuki,Toru Kimura,Michihiro Tateyama,Tatsushi Tanaka,Takuya Yazawa,Yu Arimasu,I-Shan Chen,Kohei Aoyama,Yoshihiro Kubo,Shinji Saitoh,Haruo Mizuno,Haruo Mizuno,Hiroshi Kamma +13 more
TL;DR: It is shown that SLC26A7 functions as a novel iodide transporter in the thyroid and its dysfunction affects thyroid hormonogenesis in humans and causes congenital goitrous hypothyroidism.
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Ivermectin activates GIRK channels in a PIP2-dependent, Gβγ-independent manner and an amino acid residue at the slide helix governs the activation
I-Shan Chen,I-Shan Chen,Michihiro Tateyama,Michihiro Tateyama,Yuko Fukata,Yuko Fukata,Motonari Uesugi,Yoshihiro Kubo,Yoshihiro Kubo +8 more
TL;DR: In this paper, the authors found that the G-protein-gated inwardly rectifying K+ (GIRK) channel is activated by IVM directly in a Gβγ-independent manner, but the activation is dependent on phosphatidylinositol-4,5-biphosphate (PIP2).
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A ciliary opsin in the brain of a marine annelid zooplankton is ultraviolet-sensitive, and the sensitivity is tuned by a single amino acid residue
TL;DR: It is demonstrated that the c-opsin can sense UV to activate intracellular signaling cascades and that it can directly bind exogenous all-trans-retinal in the brain of Platynereis dumerilii, suggesting that this c-opin regulates circadian signaling in a UV-dependent manner and thatIt does not require a supply of 11-cis-reteral for photoreception.
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Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells
TL;DR: SOC activity in PASMCs was stimulated by the inhibition of PKG and PKA and the activation of PKC, suggesting that the SOC could be a substrate of these protein kinases, which would regulate the intracellular concentration of calcium and pulmonary arteriopathy via SOC.