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Motonari Uesugi

Researcher at Kyoto University

Publications -  156
Citations -  4089

Motonari Uesugi is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Small molecule. The author has an hindex of 34, co-authored 144 publications receiving 3625 citations. Previous affiliations of Motonari Uesugi include Tokyo University of Agriculture and Technology & Baylor College of Medicine.

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A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions

TL;DR: Combined use of KY02111 and WNT signaling modulators produced robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin.
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A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

TL;DR: The analysis suggests that fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain.
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Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.

TL;DR: The candidate tumor suppressor ING1 was identified in a genetic screen aimed at isolation of human genes whose expression is suppressed in cancer cells as mentioned in this paper, but its molecular mechanism is not clear.