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Ian Clark-Lewis
Researcher at University of British Columbia
Publications - 23
Citations - 3356
Ian Clark-Lewis is an academic researcher from University of British Columbia. The author has contributed to research in topics: Chemokine & Receptor. The author has an hindex of 15, co-authored 23 publications receiving 3242 citations. Previous affiliations of Ian Clark-Lewis include University of California, San Diego & Princeton University.
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Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Marcel Loetscher,B Gerber,Pius Loetscher,Simon Arnett Jones,Luca Piali,Ian Clark-Lewis,Marco Baggiolini,Bernhard Moser +7 more
TL;DR: The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells.
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Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes.
TL;DR: Owing to their superior effectiveness on CD4+ and CD8+ T cells, the monocyte chemotactic proteins could play a major role in the recruitment of activated T lymphocytes.
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Neutrophil activation by monomeric interleukin-8
Krishna Rajarathnam,B.D. Sykes,Cyril M. Kay,Beatrice Dewald,Thomas Geiser,Marco Baggiolini,Ian Clark-Lewis +6 more
TL;DR: An IL-8 analog was chemically synthesized, with the amide nitrogen of leucine-25 methylated to selectivity block formation of hydrogen bonds between monomers and thereby prevent dimerization.
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Neutrophil-activating properties of the melanoma growth-stimulatory activity.
TL;DR: It is demonstrated that MGSA is a potent inflammatory agonist with neutrophil-stimulating properties, apart from its growth-stimulatory activity, and intradermal injections of MGSA resulted in a massive accumulation of neutrophils.
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The interleukin-8-related chemotactic cytokines GRO alpha, GRO beta, and GRO gamma activate human neutrophil and basophil leukocytes.
TL;DR: It can be concluded that GRO alpha, GRO beta, and GRO gamma have the same pattern of activity toward human granulocytes and that the differences in amino acid sequence among these proteins have only minor effects on biological activity.