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Ian M. Kerr
Researcher at Lincoln's Inn
Publications - 122
Citations - 18266
Ian M. Kerr is an academic researcher from Lincoln's Inn. The author has contributed to research in topics: Interferon & RNA. The author has an hindex of 66, co-authored 122 publications receiving 17935 citations. Previous affiliations of Ian M. Kerr include National Institute for Medical Research & Cancer Research UK.
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How cells respond to interferons
TL;DR: The Janus kinases and signal transducers and activators of transcription, and many of the interferon-induced proteins, play important alternative roles in cells, raising interesting questions as to how the responses to the interFERons intersect with more general aspects of cellular physiology and how the specificity of cytokine responses is maintained.
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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
Eliane F. Meurs,Karen Chong,Julien Galabru,N.Shaun B. Thomas,Ian M. Kerr,Bryan R.G. Williams,Bryan R.G. Williams,Ara G. Hovanessian +7 more
TL;DR: The molecular cloning and characterization of several related cDNAs from which can be deduced the full-length p68 kinase sequence are reported, which predicts a protein of 550 amino acids containing all of the conserved domains specific for members of the protein kinase family.
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Jaks and Stats in signaling by the cytokine receptor superfamily
James N. Ihle,Ian M. Kerr +1 more
TL;DR: The membrane-distal region, which contains the major sites of tyrosineosphorylation, is required for phosphorylation of SHC and p85, not for mitogenesis, thus allowing functional dissection of the signaling pathways activated by cytokines.
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pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells
Ian M. Kerr,Ronald E. Brown +1 more
TL;DR: A low molecular weight inhibitor of cell-free protein synthesis effective at subnanomolar concentrations is formed on incubation of cytoplasmic extracts from interferon-treated cells with double-stranded RNA and ATP.
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Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
Richard L. Friedman,Susan P. Manly,Martin McMahon,Ian M. Kerr,George Stark Stark,George Stark Stark +5 more
TL;DR: Eighteen cDNAs, cloned from interferon-treated T98G neuroblastoma cells, correspond to seven different mRNAs induced up to 40-fold by interferons, and one codes for metallothionein II and another for a class I HLA.