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Ian R. Pottie
Researcher at Saint Mary's University
Publications - 26
Citations - 222
Ian R. Pottie is an academic researcher from Saint Mary's University. The author has contributed to research in topics: Butyrylcholinesterase & Triazene. The author has an hindex of 8, co-authored 25 publications receiving 179 citations. Previous affiliations of Ian R. Pottie include Mount Saint Vincent University.
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Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants
Sultan Darvesh,Ian R. Pottie,Katherine V. Darvesh,Robert S. McDonald,Ryan Walsh,Sarah Conrad,Andrea Penwell,Diane Mataija,Earl Martin +8 more
TL;DR: The comparative effects of aminoureas on wild-type BuChE and several BuE mutants indicate a binding process involving salt linkage with the aspartate of the cholinesterase peripheral anionic site.
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Electron Deficient Dienes. 2. One Step Synthesis of a Coumarin-Fused Electron Deficient Diene and its Inverse Electron Demand Diels-Alder Reactions with Enamines.
TL;DR: In this article, a coumarin-fused electron deficient diene was prepared by the base-induced reaction of dimethyl glutaconate and salicalde- hyde, which gave, after in situ elimination and dehydrogenation, benzocoumarins.
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2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease.
Katrina L. Forrestall,Darcy E. Burley,Meghan K. Cash,Ian R. Pottie,Sultan Darvesh,Sultan Darvesh +5 more
TL;DR: 2-pyridone natural products with calculated potent inhibitory activity against SARS-CoV-2 Mpro and with desirable drug-like properties are identified and may lead to the rapid discovery of a treatment for COVID-19.
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1,2-Bis(1-aryl-3-alkyltriazen-3-yl)ethanes and related compounds
TL;DR: A series of novel bistriazenes, the 1,2-bis(1-aryl-3methyltriazen-3-yl)ethanes, have been synthesized by diazonium coupling with N,N'-dimethylethylenediamine as mentioned in this paper.
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Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
Drew R. DeBay,Drew R. DeBay,George Andrew Reid,Ian R. Pottie,Ian R. Pottie,Earl Martin,Chris V. Bowen,Chris V. Bowen,Sultan Darvesh +8 more
TL;DR: Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on B ChE pathology in the cerebral cortex, a region of scant BChE activity in healthy brain.