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Ian Wilmut
Researcher at University of Edinburgh
Publications - 264
Citations - 25328
Ian Wilmut is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Induced pluripotent stem cell & Embryo. The author has an hindex of 67, co-authored 263 publications receiving 24508 citations. Previous affiliations of Ian Wilmut include Biotechnology and Biological Sciences Research Council & Agricultural and Food Research Council.
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Viable offspring derived from fetal and adult mammalian cells
TL;DR: The birth of lambs from differentiated fetal and adult cells confirms that differentiation of that cell did not involve the irreversible modification of genetic material required for development to term and reinforces previous speculation that by inducing donor cells to become quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
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Sheep cloned by nuclear transfer from a cultured cell line
TL;DR: This is the first report, to the authors' knowledge, of live mammalian offspring following nuclear transfer from an established cell line, and will provide the same powerful opportunities for analysis and modification of gene function in livestock species that are available in the mouse through the use of embryonic stem cells.
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Erratum: Viable offspring derived from fetal and adult mammalian cells
TL;DR: In this Letter in the 27 February issue, a production error led to the image for part b of Fig. 1 (fetal fibroblasts) being used twice, as parts b and c.
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Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts
Angelika Schnieke,Alexander Kind,W. A. Ritchie,Karen Mycock,A Scott,Marjorie Ritchie,Ian Wilmut,Alan Colman,Keith H.S. Campbell +8 more
TL;DR: Ovine primary fetal fibroblasts were cotransfected with a neomycin resistance marker gene (neo) and a human coagulation factor IX genomic construct designed for expression of the encoded protein in sheep milk and produced viable animals by nuclear transfer.
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Large offspring syndrome in cattle and sheep.
TL;DR: Four different situations have been identified that result in the large offspring syndrome: in vitro embryo culture, asynchronous embryo transfer into an advanced uterine environment, nuclear transfer and maternal exposure to excessively high urea diets.