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Igor A. Dyachenko
Researcher at Russian Academy of Sciences
Publications - 56
Citations - 565
Igor A. Dyachenko is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 40 publications receiving 446 citations.
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Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo
Denis G. Ilyushin,Ivan V. Smirnov,Ivan V. Smirnov,Alexey A. Belogurov,Igor A. Dyachenko,Tatiana Iu. Zharmukhamedova,Tatjana I. Novozhilova,Eugene A. Bychikhin,Marina V. Serebryakova,Oleg N. Kharybin,A. N. Murashev,Konstantin A. Anikienko,Eugene N. Nikolaev,Natalia A. Ponomarenko,Dmitry Genkin,G. Michael Blackburn,Patrick Masson,Alexander G. Gabibov,Alexander G. Gabibov +18 more
TL;DR: Polysialylation gives bioscavengers with enhanced pharmacokinetics which protect mice against 4.2 LD50 of S-(2-(diethylamino)ethyl) O-isobutyl methanephosphonothioate without perturbation of long-term behavior.
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Sea Anemone Peptide with Uncommon β-Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic Activity
Dmitry I. Osmakov,Sergey A. Kozlov,Yaroslav A. Andreev,Sergey G. Koshelev,Nadezhda Sanamyan,Karen Sanamyan,Igor A. Dyachenko,Dmitry A. Bondarenko,A. N. Murashev,Konstantin S. Mineev,Alexander S. Arseniev,Eugene V. Grishin +11 more
TL;DR: A new peptide, Ugr 9-1, was isolated from the sea anemone venom and was shown to inhibit the acid-sensing ion channel 3 (ASIC3) channel, which affects the ASIC3 channel, produces analgesic effects, and has a unique spatial structure and mechanism of action.
Journal ArticleDOI
Polypeptide modulators of TRPV1 produce analgesia without hyperthermia.
Yaroslav A. Andreev,Sergey A. Kozlov,Yuliya V. Korolkova,Igor A. Dyachenko,Dmitrii A. Bondarenko,Denis I. Skobtsov,A. N. Murashev,Polina D. Kotova,Olga A. Rogachevskaja,N. V. Kabanova,Stanislav S. Kolesnikov,Eugene V. Grishin +11 more
TL;DR: The polypeptides APHC1 and APHC3 could be referred to as a new class of TRPV1 modulators that produce a significant analgesic effect without hyperthermia.
Journal ArticleDOI
New polypeptide components from the Heteractis crispa sea anemone with analgesic activity
Sergey A. Kozlov,Ya. A. Andreev,A. N. Murashev,D. I. Skobtsov,Igor A. Dyachenko,E. V. Grishin +5 more
TL;DR: An interesting biological function of the new polypeptides was their analgesic effect on mammals, which is possibly realized via the modulation of the activity of the TRPV1 receptor and was not associated with the residual inhibiting activity towards trypsin and chymotrypsin.
Journal ArticleDOI
New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties
Yulia A. Logashina,Yulia A. Logashina,Runar Gjerp Solstad,Konstantin S. Mineev,Konstantin S. Mineev,Yuliya V. Korolkova,Irina V. Mosharova,Igor A. Dyachenko,Victor A. Palikov,Yulia A. Palikova,Yulia A. Palikova,A. N. Murashev,Alexander S. Arseniev,Sergey A. Kozlov,Klara Stensvåg,Tor Haug,Yaroslav A. Andreev,Yaroslav A. Andreev +17 more
TL;DR: Ueq 12-1 is a unique peptide potentiator of the TRPA1 receptor that produces analgesic and anti-inflammatory effects in vivo and is considered as a potential analgesic drug lead with antibacterial properties.