Igor Marques

TL;DR: It is demonstrated the superiority of halogen bonding over hydrogen bonding for strong anion binding in water, to the extent that halide recognition by a simple acyclic mono-charged receptor is achievable.

TL;DR: It is shown that squaramide-based ion transporters enhance the transport of chloride anions in liposomal models and promote sodium chloride influx into the cytosol and is the first experimental evidence that synthetic ion transporter can disrupt both autophagy and induce apoptosis.

TL;DR: It is demonstrated, by 1H NMR and DFT calculations, that the chalcogen atoms oriented within the macrocycle cavity are able to chelate copper(I) endotopically, and the first examples of mechanically interlocked [2]rotaxanes containing ChB-donor groups are prepared via an active metal template strategy.

TL;DR: A novel strategy for the recognition of anions in water using charge-neutral σ-hole halogen and chalcogen bonding acyclic hosts is demonstrated for the first time, and the first example of an all-chalcogenonding anion receptor in pure water is presented.

TL;DR: The unprecedented application of a chiral halogen-bonding [3]rotaxane host system for the discrimination of stereo- and E/Z geometric isomers of a dicarboxylate anion guest is described, revealing the critical synergy of halogen and hydrogen bonding interactions in anion discrimination.