W
Wan Namkung
Researcher at Yonsei University
Publications - 109
Citations - 4087
Wan Namkung is an academic researcher from Yonsei University. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Medicine. The author has an hindex of 30, co-authored 88 publications receiving 3491 citations. Previous affiliations of Wan Namkung include University of California, San Francisco.
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Journal ArticleDOI
TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells *
TL;DR: It is concluded that TMEM16A carries nearly all CaCCCurrent current in salivary gland epithelium, but is a minor contributor to total CaCC current in airway and intestinal epithelia, and potential development candidates for drug therapy of hypertension, pain, diarrhea, and excessive mucus production.
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Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells
Sung Kyun Ko,Sung Kuk Kim,Andrew Share,Vincent M. Lynch,Jinhong Park,Wan Namkung,Wim Van Rossom,Nathalie Busschaert,Philip A. Gale,Jonathan L. Sessler,Injae Shin +10 more
TL;DR: It is shown that two pyridine diamide-strapped calix[4]pyrroles induce coupled chloride anion and sodium cation transport in both liposomal models and cells, and promote cell death by increasing intracellular chloride and sodium ion concentrations.
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Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.
TL;DR: Small-molecule CaCC inhibitors may be useful in pharmacological dissection of CaCC functions and in reducing intestinal fluid losses in CaCC-mediated secretory diarrheas.
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Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
TL;DR: Tannic acid, red wine, and green tea inhibited arterial smooth muscle contraction and intestinal Cl− secretion, and gallotannins are thus potent CaCC inhibitors whose biological activity provides a potential molecular basis for the cardioprotective and antisecretory benefits of red wine and greenTea.
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A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations
Nathalie Busschaert,Seong Hyun Park,Kyung Hwa Baek,Yoon Pyo Choi,Jinhong Park,Ethan N. W. Howe,Jennifer R. Hiscock,Louise E. Karagiannidis,Igor Marques,Vítor Félix,Wan Namkung,Jonathan L. Sessler,Philip A. Gale,Injae Shin +13 more
TL;DR: It is shown that squaramide-based ion transporters enhance the transport of chloride anions in liposomal models and promote sodium chloride influx into the cytosol and is the first experimental evidence that synthetic ion transporter can disrupt both autophagy and induce apoptosis.