I
Iharilalao Dubail
Researcher at Paris Descartes University
Publications - 28
Citations - 1591
Iharilalao Dubail is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Francisella tularensis & Virulence. The author has an hindex of 22, co-authored 28 publications receiving 1510 citations. Previous affiliations of Iharilalao Dubail include French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Identification of the agr Locus of Listeria monocytogenes: Role in Bacterial Virulence
TL;DR: A new round of STM allowed us to identify a new locus encoding a protein homologous to AgrA, the well-studied response regulator of Staphylococcus aureus and part of a two-component system involved in bacterial virulence.
Journal ArticleDOI
Glutathione provides a source of cysteine essential for intracellular multiplication of Francisella tularensis.
Khaled Alkhuder,Karin L. Meibom,Karin L. Meibom,Iharilalao Dubail,Iharilalao Dubail,Marion Dupuis,Marion Dupuis,Alain Charbit,Alain Charbit +8 more
TL;DR: Evidence is presented that the capacity this intracellular bacterial pathogen has evolved to utilize the available GSH, as a source of cysteine in the host cytosol, constitutes a paradigm of bacteria–host adaptation.
Journal ArticleDOI
The sortase SrtA of Listeria monocytogenes is involved in processing of internalin and in virulence
Caroline Garandeau,Hélène Réglier-Poupet,Iharilalao Dubail,Jean-Luc Beretti,Patrick Berche,Alain Charbit +5 more
TL;DR: It is demonstrated that srtA of L. monocytogenes acts as a sortase and plays a role in the pathogenicity.
Journal ArticleDOI
Identification of new genes involved in the virulence of Listeria monocytogenes by signature-tagged transposon mutagenesis.
TL;DR: Signature-tagged transposon mutagenesis is adapted to L. monocytogenes to identify new genes involved in virulence in the murine model of infection, leading to the identification of 10 distinct loci, 7 of which corresponded to previously unknown genes.
Journal ArticleDOI
Role of the wbt Locus of Francisella tularensis in Lipopolysaccharide O-Antigen Biogenesis and Pathogenicity
Catherine Raynaud,Catherine Raynaud,Karin L. Meibom,Karin L. Meibom,Marie-Annick Lety,Marie-Annick Lety,Iharilalao Dubail,Iharilalao Dubail,Thomas Candela,Eric Frapy,Eric Frapy,Alain Charbit,Alain Charbit +12 more
TL;DR: Inactivation of wbtA led to the complete loss of O antigen, conferred serum sensitivity, impaired intracellular replication, and severely attenuated virulence in the mouse model, ensuring protection against a challenge against virulent LVS.