Marion Dupuis

TL;DR: The findings suggest that the CD8+ hyperlymphocytosis commonly observed in HIV infection is driven mainly by virus replication, through intense, continuous activation of HIV-specificCD8+ T cells until ultimate progression toward disease.

TL;DR: The weakness of the immune response during HIV PI could partially account for the failure to control HIV and have potential importance for defining immunotherapeutic strategies and establishing the goals for effective vaccination.

TL;DR: Evidence is presented that the capacity this intracellular bacterial pathogen has evolved to utilize the available GSH, as a source of cysteine in the host cytosol, constitutes a paradigm of bacteria–host adaptation.

TL;DR: It is demonstrated that Hfq promotes resistance to several cellular stresses and appears to be a new pleiotropic regulator of virulence in F. tularensis, acting mostly as a repressor, in contrast to the other regulators identified so far.

TL;DR: It is demonstrated here that ClpB of F. tularensis live vaccine strain (LVS) is important for resistance to cellular stress and promoter analysis shows that the transcriptional start is preceded by a σ32‐like promoter sequence and expression of clpB is induced by heat shock, indicating that expression of ClpP is dependent on the heat‐shock response mediated by ρ32, the only alternative σ‐factor present in Francisella.