Ikuo Miyahisa

TL;DR: In this article, the authors developed a system for producing "unnatural" flavonoids and stilbenes in Escherichia coli, which included a substrate synthesis step for CoA esters synthesis from carboxylic acids by 4-coumarate:CoA ligase, a polyketide synthesis stage for conversion of the co-a esters into flavanones, and a modification step for modification of the flavanone by flavone synthase, flavone 3beta-hydroxylase and flavonol synthase.

TL;DR: The fermentative production of flavanones in E. coli is the first step in the construction of a library of flavonoid compounds and un-natural flavonoids in bacteria.

TL;DR: The combinatorial biosynthesis of the flavones and flavonols in E. coli is promising for the construction of a library of various flavonoid compounds and un-natural flavonoids in bacteria.

TL;DR: In this paper, a cocrystal structure of a pyrazolo[1,5-a]pyridine derivative with Mcl-1 protein was successfully determined and revealed the protein-ligand binding mode.

TL;DR: For production of genistein from N-acetylcysteamine-attached p-coumarate (p- coumaroyl-NAC) supplemented to the medium, a chalcone synthase (CHS) gene from Glycyrrhiza echinata, aChalcone isomerase ( CHI) genefrom Pueraria lobata, and an isoflavone synthase(IFS) genes from G. echinATA