There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

N-Heterocyclic Carbenes in Late Transition Metal Catalysis

The fascinating story of olefin (or alkene) metathesis (eq
1) began almost five decades ago, when Anderson and
Merckling reported the first carbon-carbon double-bond
rearrangement reaction in the titanium-catalyzed polymerization of norbornene. Nine years later, Banks and Bailey reported “a new disproportionation reaction . . . in which olefins are converted to homologues of shorter and longer carbon chains...”. In 1967, Calderon and co-workers named this metal-catalyzed redistribution of carbon-carbon double bonds olefin metathesis, from the Greek word “μeτάθeση”, which means change of position. These contributions have since served as the foundation for an amazing research field, and olefin metathesis currently represents a powerful transformation in chemical synthesis, attracting a vast amount of interest both in industry and academia.

https://core.ac.uk/download/pdf/4884240.pdf

Ruthenium-based heterocyclic carbene-coordinated olefin metathesis catalysts.

The Golden Age of Transfer Hydrogenation

Selected Recent Advances in the Synthesis of Bioactive Compounds Using Olefin Metathesis as a Key Step

Lanthanide coordination polymers containing 1,3-bis(carboxymethyl) imidazolium as organic ligand: Crystal structure and luminescent properties

Synthesis of Castanospermine and Epimers by Metathesis Routes

Novel luminescent heterobimetallic Ln–Cu(I) 3D coordination polymers based on 5-(4-pyridyl) isophthalic acid as heteroleptic ligand. Synthesis and structural characterization

This account surveys the current progress on the application of intra- and intermolecular enyne metathesis as main key steps in the synthesis of challenging structural motifs and stereochemistries found in bioactive compounds. Special emphasis is placed on ruthenium catalysts as promoters of enyne metathesis to build the desired 1,3-dienic units. The advantageous association of this approach with name reactions like Grignard, Wittig, Diels–Alder, Suzuki–Miyaura, Heck cross-coupling, etc. is illustrated. Examples unveil the generality of such tandem reactions in providing not only the intricate structures of known, in vivo effective substances but also for designing chemically modified analogs as valid alternatives for further therapeutic agents.

https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-16-68.pdf

Ileana Dragutan

Papers

Selected Recent Advances in the Synthesis of Bioactive Compounds Using Olefin Metathesis as a Key Step

Lanthanide coordination polymers containing 1,3-bis(carboxymethyl) imidazolium as organic ligand: Crystal structure and luminescent properties

Synthesis of Castanospermine and Epimers by Metathesis Routes

Novel luminescent heterobimetallic Ln–Cu(I) 3D coordination polymers based on 5-(4-pyridyl) isophthalic acid as heteroleptic ligand. Synthesis and structural characterization

Combining enyne metathesis with long-established organic transformations: a powerful strategy for the sustainable synthesis of bioactive molecules.