Inchan Kwon

TL;DR: The findings show that erythrosine B (ER) is a novel modulator of Aβ aggregation and reduces Aβ-associated impaired cell function and suggest that xanthene dye can be a new type of small molecule modulators of A β aggregation.

TL;DR: It is demonstrated that biocompatible pluronic-based nanocarriers can be used to deliver a target therapeutic protein along with its toxicity-eliminating agent in order to reduce side effects and enhance efficacy and co-delivery of UOX and AuNPs using NCs significantly improves in vivo UA degradation.

TL;DR: In this paper, a modified aminoacyl-tRNA synthetase was used to charge nonstandard amino acids to a modified tRNA, which formed strict Watson-Crick base-pairing with a codon that normally forms wobble base pairing with natural tRNAs.

TL;DR: This review describes bioorthogonal reactions useful for protein conjugation, and biosynthetic methods that produce proteins amenable to those reactions through an expanded genetic code, and provides key examples in which novelprotein conjugates, generated by the genetic incorporation of a non-natural amino acid and the chemoselective reactions, address unmet needs in protein therapeutics and enzyme engineering.

TL;DR: This review summarizes the recent advances in bioorthogonal chemistries and suggests that the site-specific polymer conjugation technique would be a valuable platform technique to design novel protein–polymer conjugates.