Showing papers in "Journal of Controlled Release in 2019"

TL;DR: This review is thus organized to critically assess the significant role of nanotechnology for encapsulation of AIs for pesticides and the future trends of pesticide nanoformulations including nanomaterials as AIs and nanoemulsions of biopesticides are explored.

TL;DR: BPQD‐RMNV‐mediated PTT combined with immune checkpoint blockade antibody increased the infiltration and activity of CD8+ T cells in the tumor, which directly restrained basal‐like breast tumor growth in vivo.

TL;DR: The basic principles of electrospinning, and the mechanisms and applications of Electrospun micro/nanofibers for delivery of small molecule drugs, proteins, and nucleic acids in the healthcare field are introduced.

TL;DR: The interest and the potential of Pickering emulsions for pharmaceutical applications are exposed and discussed, taking all the administration routes into consideration and focusing on organic particles.

TL;DR: New analytical methods were developed to determine the branch number of star-shaped PLGAs, and to separatePLGAs based on L:G ratios regardless of the molecular weight, which are important for further development of not only PLGA depot formulations with controllable drug release kinetics, but also generic formulations of current brand-name products.

TL;DR: Carbon nanotubes, graphene-based nanomaterials, micelles and hydrogels-all delivery systems capable of π-π stacking interactions-are the focus and their applications to the design of drug-delivery systems are covered.

TL;DR: This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration.

TL;DR: The present review is attempting to cover the novel advances in nanoencapsulation of carotenoids principally based on lipid‐based nanocarriers with an emphasis on the factors affecting the bioaccessibility of carOTenoids in such nanoccarriers, together with their challenges and upcoming evolutions.

TL;DR: Oral treatment of APPswe/PS1dE9 mice with EGCG/AA NPs resulted in a marked increase in synapses, as judged by synaptophysin (SYP) expression, and reduction of neuroinflammation as well as amyloid &bgr; (A&b gr;) plaque burden and cortical levels of soluble and insoluble A&b Gr;(1‐42) peptide.

TL;DR: An overview of drug delivery systems which can deliver drugs to the tumor microenvironment and initiate the drug release in response to specific enzymes highly expressed in particular tumor tissues is given.

TL;DR: This work investigated the importance of plasmonic properties of AuNPs in optical manipulation, imaging, drug delivery, and photothermal therapy (PTT) of cancerous cells based on their physicochemical properties.

TL;DR: A multi‐step approach of incremental complexity to measure particle size distribution and size stability of NEPs, consisting of a quick preliminary step to assess sample integrity and stability by low resolution techniques (pre‐screening), followed by the combination of complementary high resolution sizing measurements performed both in simple buffers and in complex biological media.

TL;DR: Empirical studies in vitro and in vivo of curcumin nanoformulations, as well as human clinical trials are discussed, which can increase the solubility ofCurcumin, improve the intestinal stability of cur cumin, change the absorption route of Curcumin and allow for coadministration with other adjuvants.

TL;DR: The progresses made in magnetic drug targeting are reviewed, the systems already developed or proposed are summarized, and they are categorized into two groups: static field magnet systems and varying field magnet Systems.

TL;DR: This article describes in depth some critical issues relevant to the development of liposomes as a VADS, including principles underlying immunization, physicochemical properties of lipOSomes as the immunity-influencing factors, functional material modification to enhance immunostimulatory functions, the state-of-the-art liposome VADSs, as well as the marketed vaccines based on a liposom VADS.

TL;DR: The historical development of this approach, along with the state‐of‐the‐art, including a discussion on the role of the formulation parameters, surfactants, amphiphilic polymers, interface stabilization, volume fraction, and so forth, on the final formulation stability, morphology and properties as drug delivery system are recounted.

TL;DR: A comprehensive understanding of the antibacterial application of graphene-based nanomaterials is provided via summarizing their antibacterial activities against some typical microbial species and discussing their unique mechanisms.

TL;DR: Overall, this work provides a comprehensive overview of the utility of MSCs in drug and gene delivery as well as MSC membrane coated nanoparticles for therapy and drug delivery, aiming to figure out the significant room for development and highlight the potential future directions.

TL;DR: The present review features the outweighing benefits of combination therapy over mono‐oncotherapy and discusses several existent nanoformulation strategies that facilitate a successful combination oncotherapy.

TL;DR: This review summarizes recent progress in the design of 2D theranostic nanomaterials, functionalization methods and their applications in photothermal therapy (PTT) as well as synergistic cancer therapy and concludes the opinion on current challenges and future prospective on meeting the various demands of advanced cancer imaging and therapies.

TL;DR: A critical review of the major problems complicating the development of liposomes for AO delivery are provided, and development strategies for resolving these problems are introduced.

TL;DR: The focus of the review is to assess the technological advancements made so far in enhancing circulatory half‐lives and improving therapeutic potency of proteins.

TL;DR: This review analyses the biological considerations, material selection, and delivery strategies that have been established as the pivotal components for growth factors delivery and will support the next generation of tissue engineering platforms by providing a comprehensive landscape for the growth factor delivery field.

TL;DR: The prepared P(CPT‐MAA) prodrug nanogels exhibited superior antitumor activity both in vitro and in vivo without observed side effects, and may be a promise delivery system for chemotherapeutic agents.

TL;DR: Various mechanisms of controlled drug delivery using polymeric MNs, including new strategies, applications, and their future outlook are summarized and evaluated.

TL;DR: This review discusses two major topics: first, the application of eutectic mixtures (before and after the introduction of DES) in the field of drug delivery systems, and second, the most promising examples of DES pharmaceutical activity.

TL;DR: The U.S. National Cancer Institute has announced that it will stop funding its Centers of Cancer Nanotechnology Excellence (CCNEs), and it is time to review the progress made in nanomedicine, and examine the sources of difficulty in clinical translation, and move forward.

TL;DR: It is demonstrated that ZANPs may be a safe and effective vehicle for the development of cancer vaccines by taking advantage of a natural biomineralization process to create aluminum-containing nanoZIF-8 particles for antigen delivery.

TL;DR: Although flavonoids offer tremendous potential in healing the skin conditions categorically, its clinical translation needs in depth safety and efficacy data, meeting established regulatory standards.

TL;DR: This review highlights the development of thermosensitive and pH-sensitive liposomes, focusing on liposomal compositions and the effects of the synthetic polymers on their drug release behavior.