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Inga Koneczny
Researcher at Medical University of Vienna
Publications - 29
Citations - 907
Inga Koneczny is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Myasthenia gravis & Autoantibody. The author has an hindex of 13, co-authored 25 publications receiving 645 citations. Previous affiliations of Inga Koneczny include Maastricht University & John Radcliffe Hospital.
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MuSK Myasthenia Gravis IgG4 Disrupts the Interaction of LRP4 with MuSK but Both IgG4 and IgG1-3 Can Disperse Preformed Agrin-Independent AChR Clusters
TL;DR: Interference by IgG4 antibodies of the LRP4-MuSK interaction will be one pathogenic mechanism of MuSK antibodies, but IgG1-3MuSK antibodies will also contribute to the reduced AChR density and neuromuscular dysfunction in myasthenia patients with Mu SK antibodies.
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A New Classification System for IgG4 Autoantibodies.
TL;DR: A modified classification system based on Witebsky’s postulates is established to determine IgG 4 pathogenicity in IgG4 autoimmune diseases, review characteristics and pathogenic mechanisms of IgG3 in these disorders, and investigate the contribution of other antibody entities to pathophysiology by additional mechanisms.
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Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture.
Inga Koneczny,Ruth Herbst +1 more
TL;DR: An overview of the history and clinical aspects of MG is given, with a focus on the structure and function of myasthenic autoantigens at the NMJ and how they are affected by the autoantibodies’ pathogenic mechanisms.
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IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients.
Inga Koneczny,Jo Stevens,Anna De Rosa,Saif Huda,Maartje G. Huijbers,Abhishek Saxena,Michelangelo Maestri,Konstantinos Lazaridis,Paraskevi Zisimopoulou,Socrates J. Tzartos,Jan J.G.M. Verschuuren,Silvère M. van der Maarel,Philip Van Damme,Marc H. De Baets,Peter C. M. Molenaar,Angela Vincent,Roberta Ricciardi,Pilar Martinez-Martinez,Mario Losen +18 more
TL;DR: Fab-arm exchange with normal human IgG4 did not prevent the inhibitory effect of serum derived MuSK antibodies on AChR clustering in C2C12 mouse myotubes, demonstrating that Fab-arm exchanged antibodies are pathogenic.
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The search for new antigenic targets in myasthenia gravis.
Judith Cossins,Katsiaryna Belaya,Katarzyna Marta Zoltowska,Inga Koneczny,Susan Maxwell,Leslie Jacobson,Maria Isabel Leite,Patrick Waters,Angela Vincent,David Beeson +9 more
TL;DR: Cell‐based assays in which candidate target proteins are expressed on the cell surface of transfected cells and probed with patient sera enable us to begin to identify new antigenic targets and test antibody pathogenicity in vitro.