Analysis of ACE inhibitors in pharmaceutical dosage forms by derivative UV spectroscopy and liquid chromatography (HPLC)

Preparative chromatographic separation of enantiomers.

Enantiomers of various chiral five- and six-membered-ring lactones, Which are important classes of compounds (flavour and Pheromone components, key intermediates in the synthesis of biologically active substances) have been separated chromatographically on the chiral phase cellulose triacetate, crystallographic form I (CTAI). For different series of five-membered-ring lactones, relationships have been found between the elution order of the enantiomers and their absolute configuration. Preparative resolutions of γ-Phenyl-γ-butyrolactone (1) and of the Pheromone component 5b have been carried out to demonstrate the applicability of the method to g-scale separations.

Analytic and preparative resolution of recemic γ‐ and δ‐lactones by chromatography on cellulose triacetate. Relationship between elution order and absolute configuration

Chromatographic investigation of the slowly interconverting atropisomers of hindered naphthamides

Liquid chromatography-mass spectrometry method for determination of ramipril and its active metabolite ramiprilat in human plasma.

Multiple peak formation in reversed-phase liquid chromatography of ramipril and ramiprilate

Cis-trans isomerization of an angiotensin I-converting enzyme inhibitor. An enzyme kinetic and nuclear magnetic resonance study.

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Studies of Chiral Indoles. Part II: Conformational Analysis of 1- and 3-(1-Phenylethyl) Indoles. A Dynamic 1H NMR, Molecular Mechanics, and Circular Dichroism Investigation.

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Studies of Chiral Indoles. Part I. Indoles with Chiral 1- and 3-Substituents. Synthesis and Preparative Enantiomeric Separation by Chromatography on Microcrystalline Triacetylcellulose.

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Ingemar Nilsson

Papers

Multiple peak formation in reversed-phase liquid chromatography of ramipril and ramiprilate

Cis-trans isomerization of an angiotensin I-converting enzyme inhibitor. An enzyme kinetic and nuclear magnetic resonance study.

Studies of Chiral Indoles. Part II: Conformational Analysis of 1- and 3-(1-Phenylethyl) Indoles. A Dynamic 1H NMR, Molecular Mechanics, and Circular Dichroism Investigation.

Studies of Chiral Indoles. Part I. Indoles with Chiral 1- and 3-Substituents. Synthesis and Preparative Enantiomeric Separation by Chromatography on Microcrystalline Triacetylcellulose.

Studies of Chiral Indoles. Part III. The Absolute Configuration of 1-(1-Phenylethyl)indole.