Ingrid Swanson Pultz

TL;DR: Through identification of a natural enzyme with the pre-existing qualities relevant to an ultimate goal and redefinition of its substrate specificity using computational modeling, this work was able to generate an enzyme with potential as a therapeutic for celiac disease.

TL;DR: In this article, a review highlights important questions in research into the mechanisms of cyclic-di-GMP signalling and its role in bacterial physiology and highlights the importance of protein-protein interactions.

TL;DR: Evidence is presented that c‐di‐GMP signalling specificity is achieved through differences in affinities of receptor macromolecules, and PilZ domain proteins of Pseudomonas aeruginosa demonstrated a 145‐fold difference in binding affinITIES, suggesting that regulation by binding affinity may be a conserved mechanism that allows organisms with many c‐ di‐G MP binding macromolescules to rapidly integrate multiple environmental signals into one output.

TL;DR: Kuma030 is capable of degrading >99% of the immunogenic gliadin fraction in laboratory-simulated gastric digestions within physiologically relevant time frames, suggesting great potential for this enzyme as an oral therapeutic for celiac disease.

TL;DR: The production of even chain length alkanes represents initial steps toward the expansion of this recently discovered microbial alkane production pathway to synthesize complex fuels.