Ingrid van der Heijden

TL;DR: Investigation of the interaction between prostaglandins and members of the ATP-binding cassette (ABC) transporter ABCC [multidrug resistance protein (MRP)] family of membrane export pumps suggests that MRP4 can release prostaglandsins from cells, and that some nonsteroidal antiinflammatory drugs might also act by inhibiting this release.

TL;DR: A physiological role for MRP1 and MRP4 in DHEAS transport and an involvement of MRp4 in transport of conjugated steroids and bile acids are suggested.

TL;DR: The results underline the promise of in vivo responses of “spontaneous” Brca1- and p53-deficient mammary tumors arising in conditional mouse mutants to treatment with doxorubicin, docetaxel, or cisplatin for the study of tumor-initiating cells and of drug therapy of human cancer.

TL;DR: A mechanistic link between the loss of p53 in cancer cells, secretion of WNT ligands and systemic neutrophilia that potentiates metastatic progression is demonstrated, illustrating the importance of the genetic makeup of breast tumours in dictating pro-metastatic systemic inflammation.

TL;DR: The data indicate that MRP4 and MRP5 are low affinity cyclic nucleotide transporters that may at best function as overflow pumps, decreasing steep increases in cGMP levels under conditions where cG MP synthesis is strongly induced and phosphodiesterase activity is limiting.