N
Noam Zelcer
Researcher at University of California, Los Angeles
Publications - 57
Citations - 8200
Noam Zelcer is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Liver X receptor & LDL receptor. The author has an hindex of 31, co-authored 47 publications receiving 7615 citations. Previous affiliations of Noam Zelcer include Netherlands Cancer Institute & University of Amsterdam.
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Journal ArticleDOI
Liver X receptors as integrators of metabolic and inflammatory signaling.
Noam Zelcer,Peter Tontonoz +1 more
TL;DR: The liver X receptors are nuclear receptors that play central roles in the transcriptional control of lipid metabolism and are particularly attractive targets for intervention in human metabolic disease.
Journal ArticleDOI
ApoE Promotes the Proteolytic Degradation of Aβ
Qingguang Jiang,C. Y. Daniel Lee,Shweta Mandrekar,Brandy L. Wilkinson,Paige E. Cramer,Noam Zelcer,Karen Mann,Bruce T. Lamb,Timothy M. Willson,Jon L. Collins,Jill C. Richardson,Jonathan D. Smith,Thomas A. Comery,David Riddell,David M. Holtzman,Peter Tontonoz,Gary E. Landreth +16 more
TL;DR: Apolipoprotein E plays a role in facilitating the proteolytic clearance of soluble Abeta from the brain and LXR agonists may represent a novel therapy for AD.
Journal ArticleDOI
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
TL;DR: It is shown that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeostasis, not only through promotion of cholesterol efflux but also through suppression of low-density lipoprotein (LDL) uptake.
Journal ArticleDOI
LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
Steven J. Bensinger,Michelle N. Bradley,Sean B. Joseph,Noam Zelcer,Edith M. Janssen,Mary Ann Hausner,Roger Shih,John S. Parks,Peter A. Edwards,Beth D. Jamieson,Peter Tontonoz +10 more
TL;DR: It is demonstrated that cellular cholesterol levels in dividing T cells are maintained in part through reciprocal regulation of the LXR and SREBP transcriptional programs, and implicate LXR signaling in a metabolic checkpoint that modulates cell proliferation and immunity.
Journal ArticleDOI
Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR
Noelia A-Gonzalez,Steven J. Bensinger,Cynthia Hong,Susana Beceiro,Michelle N. Bradley,Noam Zelcer,Jose M. Déniz,Cristina M. Ramírez,Mercedes Diaz,Germán Gallardo,Carlos M. Ruiz de Galarreta,Jon Salazar,Félix A. López,Peter A. Edwards,John S. Parks,Miguel Andújar,Peter Tontonoz,Antonio Castrillo,Antonio Castrillo +18 more
TL;DR: It is found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance and treatment with an LXR agonist ameliorated disease progression in a mouse model of lupus-like autoimmunity.