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Irene M. van Langen
Researcher at University Medical Center Groningen
Publications - 91
Citations - 6030
Irene M. van Langen is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Sudden death & Population. The author has an hindex of 37, co-authored 87 publications receiving 5263 citations. Previous affiliations of Irene M. van Langen include University of Groningen.
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Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases
Philippe Charron,Michael Arad,Michael Arad,Eloisa Arbustini,Cristina Basso,Zofia T. Bilińska,Perry M. Elliott,Tiina Heliö,Andre Keren,William J. McKenna,Lorenzo Monserrat,Sabine Pankuweit,Andreas Perrot,Claudio Rapezzi,Arsen D. Ristić,Hubert Seggewiss,Irene M. van Langen,Luigi Tavazzi +17 more
TL;DR: The aims of this position statement are to review the general issues related to genetic counselling, family screening and genetic testing in families with a cardiomyopathy, and to provide key messages and suggestions for clinicians involved in their management.
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Sudden Unexplained Death Heritability and Diagnostic Yield of Cardiological and Genetic Examination in Surviving Relatives
TL;DR: Examination of relatives of young SUD victims has a high diagnostic yield, with identification of the disease in 40% of families and 8.9 presymptomatic carriers per family.
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Plakophilin-2 Mutations Are the Major Determinant of Familial Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
J. Peter van Tintelen,Mark M. Entius,Zahurul A. Bhuiyan,Roselie Jongbloed,Ans C.P. Wiesfeld,Arthur A.M. Wilde,Jasper J. van der Smagt,Ludolf G. Boven,Marcel M.A.M. Mannens,Irene M. van Langen,Robert M. W. Hofstra,Luuk C. Otterspoor,Pieter A. Doevendans,Luz-Maria Rodriguez,Isabelle C. Van Gelder,Richard N.W. Hauer +15 more
TL;DR: In this paper, mutations in the plakophilin-2 gene (PKP2) were found in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC).
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Auditory stimuli as a trigger for arrhythmic events differentiate HERG- related (LQTS2) patients from KVLQT1-related patients (LQTS1)
Arthur A.M. Wilde,Rosalie J.E. Jongbloed,Pieter A. Doevendans,Donald R. Düren,Richard N.W. Hauer,Irene M. van Langen,J. Peter van Tintelen,Hubert J.M. Smeets,Henk Meyer,Jan L.M.C Geelen +9 more
TL;DR: Whereas exercise-related cardiac events dominate the clinical picture of LQTS1 patients, auditory stimuli as a trigger for arrhythmic events were only seen in LQ TS2 patients, which suggests arrhythmic Events triggered by auditory stimuli may differentiate L QTS2 from LQts1 patients.
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A Cardiac Sodium Channel Mutation Cosegregates With a Rare Connexin40 Genotype in Familial Atrial Standstill
W. Antoinette Groenewegen,Mehran Firouzi,Connie R. Bezzina,Saskia Vliex,Irene M. van Langen,Lodewijk Sandkuijl,Jeroen P.P. Smits,Miriam Hulsbeek,Martin B. Rook,Habo J. Jongsma,Arthur A.M. Wilde +10 more
TL;DR: In this paper, the authors investigated the genetic background of atrial standstill (AS) in a large family and found that atrial-specific gap junction protein connexin40 (Cx40) was associated with the concurrence of a cardiac sodium channel mutation and rare polymorphisms in the atrial specific Cx40 gene.