Irina A. Potapova

TL;DR: It is demonstrated that genetically modified hMSCs can express functional HCN2 channels in vitro and in vivo, mimicking overexpression ofHCN2 genes in cardiac myocytes, and represent a novel delivery system for pacemaker genes into the heart or other electrical syncytia.

TL;DR: Medium conditioned by hMSC spheroids was more effective in stimulation of umbilical vein endothelial cell proliferation, migration, and basement membrane invasion than medium conditioned by a monolayer of hMSCs, suggesting that culturing of h MSCs as three‐dimensional cellular aggregates provides a method to concentrate proangiogenic factors secreted by hmsCs and allows for reduction of serum concentration in conditioned medium.

TL;DR: The novel hypothesis that non‐hybridized and possible hybridized forms of siRNA can move between mammalian cells through connexin‐specific gap junctions is supported.

TL;DR: It is demonstrated that minK-related peptide 1 (MiRP1) is a β subunit for the HCN family, and this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity.

TL;DR: Human mesenchymal stem cells (hMSCs) are a multipotent cell population with the potential to be a cellular repair or delivery system provided that they communicate with target cells such as cardiac myocytes via gap junctions.