Peter R. Brink

TL;DR: It is demonstrated that genetically modified hMSCs can express functional HCN2 channels in vitro and in vivo, mimicking overexpression ofHCN2 genes in cardiac myocytes, and represent a novel delivery system for pacemaker genes into the heart or other electrical syncytia.

TL;DR: Medium conditioned by hMSC spheroids was more effective in stimulation of umbilical vein endothelial cell proliferation, migration, and basement membrane invasion than medium conditioned by a monolayer of hMSCs, suggesting that culturing of h MSCs as three‐dimensional cellular aggregates provides a method to concentrate proangiogenic factors secreted by hmsCs and allows for reduction of serum concentration in conditioned medium.

TL;DR: The thesis of this review is that the presence of gap junctions, in concert with the autonomic nervous system, pacemaker cells, myogenic mechanisms, and/or electrotonic current spread, confers a plasticity, adaptability, and flexibility to vasculature that may well account for the observed diversity in regulation and function of vascular tissues throughout the vascular tree.

TL;DR: The novel hypothesis that non‐hybridized and possible hybridized forms of siRNA can move between mammalian cells through connexin‐specific gap junctions is supported.

TL;DR: A new model for connexin channel conductance and permselectivity based on electrostatic interactions is suggested and is not consistent with the conventional simple aqueous pore model of a gap junction channel.