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Irini Evnouchidou
Researcher at French Institute of Health and Medical Research
Publications - 33
Citations - 1634
Irini Evnouchidou is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Endosome & MHC class I. The author has an hindex of 17, co-authored 30 publications receiving 1398 citations. Previous affiliations of Irini Evnouchidou include Paris Diderot University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
Tina T Nguyen,Shih-Chung Chang,Shih-Chung Chang,Irini Evnouchidou,Ian A. York,Ian A. York,Christos Zikos,Kenneth L. Rock,Alfred L. Goldberg,Efstratios Stratikos,Lawrence J. Stern +10 more
TL;DR: Structural and biochemical analyses suggest a mechanism for ERAP1's length-dependent trimming activity, whereby binding of long rather than short substrates induces a conformational change with reorientation of a key catalytic residue toward the active site.
Journal Article
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1
Tina T Nguyen,Shih-Chung Chang,Irini Evnouchidou,Ian A. York,Kenneth L. Rock,Alfred L. Goldberg,Efstratios Stratikos,Lawrence J. Stern +7 more
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Human cytomegalovirus microRNA miR-US4-1 inhibits CD8 + T cell responses by targeting the aminopeptidase ERAP1
Sungchul Kim,Sanghyun Lee,Jinwook Shin,Young-Kyun Kim,Irini Evnouchidou,Donghyun Kim,Young Kook Kim,Young Eui Kim,Jin-Hyun Ahn,Stanley R. Riddell,Efstratios Stratikos,V. Narry Kim,Kwangseog Ahn +12 more
TL;DR: It is shown that HCMV miR-US4-1 specifically downregulated ERAP1 expression during viral infection, which led to less susceptibility of infected cells to H CMV-specific cytotoxic T lymphocytes (CTLs).
Journal ArticleDOI
Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
Irini Evnouchidou,Ram P. Kamal,Sergey S. Seregin,Yoshikuni Goto,Masafumi Tsujimoto,Akira Hattori,Paraskevi V. Voulgari,Alexandros A. Drosos,Andrea Amalfitano,Ian A. York,Efstratios Stratikos +10 more
TL;DR: Cell-based Ag-presentation analysis was consistent with changes in the substrate inhibition constant Ki, supporting that ERAP1 allelic composition may affect Ag processing in vivo and proposing that these phenomena should be taken into account when evaluating the possible link between Ag processing and autoimmunity.
Journal ArticleDOI
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
Irini Evnouchidou,Frank Momburg,Athanasios Papakyriakou,Angeliki Chroni,Leondios Leondiadis,Shih-Chung Chang,Alfred L. Goldberg,Efstratios Stratikos +7 more
TL;DR: It is proposed that ERAP1 recognizes the full length of its peptide-substrate and not just the N- and C- termini, and it is possible that ER AP1 trimming preferences influence the rate of generation and the composition of antigenic peptides in vivo.