S
Shih-Chung Chang
Researcher at National Taiwan University
Publications - 34
Citations - 3900
Shih-Chung Chang is an academic researcher from National Taiwan University. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 16, co-authored 28 publications receiving 3543 citations. Previous affiliations of Shih-Chung Chang include Centers for Disease Control and Prevention & Harvard University.
Papers
More filters
Journal ArticleDOI
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides.
Tomo Saric,Shih-Chung Chang,Akira Hattori,Ian A. York,Shirley L. Markant,Kenneth L. Rock,Masafumi Tsujimoto,Alfred L. Goldberg +7 more
TL;DR: This work purified from liver microsomes a lumenal, soluble aminopeptidase that removes NH2-terminal residues from many antigenic precursors that stimulates the processing and presentation of an antigenic precursor in the ER.
Journal ArticleDOI
Docking of the Proteasomal ATPases' Carboxyl Termini in the 20S Proteasome's α Ring Opens the Gate for Substrate Entry
TL;DR: The C termini of the proteasomal ATPases function like a "key in a lock" to induce gate opening and allow substrate entry in the 20S.
Journal ArticleDOI
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.
Ian A. York,Shih-Chung Chang,Tomo Saric,Jennifer A. Keys,Janice M. Favreau,Alfred L. Goldberg,Kenneth L. Rock +6 more
TL;DR: After interferon-γ treatment, which causes proteasomes to produce more NH2-extended antigenic precursors, ERAP1 increased the supply of peptides for MHC class I antigen presentation and trimmed nearly half the nine-residue peptides tested.
Journal ArticleDOI
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases.
TL;DR: It is demonstrated how the ATPases' C termini function to facilitate substrate entry by identifying the sites in the archaeal 20S where PAN's C-terminal residues bind and determining the structures of the gate in its closed and open forms.
Journal ArticleDOI
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
Rika Draenert,Sylvie Le Gall,Katja Pfafferott,Alasdair Leslie,Polan Chetty,Christian Brander,Edward C. Holmes,Shih-Chung Chang,Margaret E. Feeney,Marylyn M. Addo,Lidia Ruiz,Danni Ramduth,P M Jeena,Marcus Altfeld,Stephanie Thomas,Yanhua Tang,Cori L. Verrill,Catherine Dixon,Julia G. Prado,Photini Kiepiela,Javier Martinez-Picado,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +23 more
TL;DR: It is demonstrated that allele-associated sequence variation within the flanking region of CTL epitopes can alter antigen processing and is of major relevance in the construction of vaccine sequences.