S
Sergey S. Seregin
Researcher at Michigan State University
Publications - 51
Citations - 1960
Sergey S. Seregin is an academic researcher from Michigan State University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 23, co-authored 50 publications receiving 1615 citations. Previous affiliations of Sergey S. Seregin include College of Osteopathic Medicine of the Pacific & University of Michigan.
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Journal ArticleDOI
NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila
Sergey S. Seregin,Natasha Golovchenko,Bryan Schaf,Jiachen Chen,Nicholas A. Pudlo,Jonathan S. Mitchell,Nancy N. Baxter,Lili Zhao,Patrick D. Schloss,Eric C. Martens,Kathryn A. Eaton,Grace Y. Chen +11 more
TL;DR: It is shown that NLRP6 is important for suppressing the development of spontaneous colitis in the Il10-/- mice model of IBD and thatNLRP6 deficiency results in the enrichment of Akkermansia muciniphila.
Journal ArticleDOI
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection
Hideki Hara,Sergey S. Seregin,Dahai Yang,Koichi Fukase,Mathias Chamaillard,Emad S. Alnemri,Naohiro Inohara,Grace Y. Chen,Gabriel Núñez +8 more
TL;DR: Results reveal a previously unrecognized innate immunity pathway triggered by cytosolic LTA that is sensed by NLRP6 and exacerbates systemic Gram-positive pathogen infection via the production of IL-18.
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Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme
Irini Evnouchidou,Ram P. Kamal,Sergey S. Seregin,Yoshikuni Goto,Masafumi Tsujimoto,Akira Hattori,Paraskevi V. Voulgari,Alexandros A. Drosos,Andrea Amalfitano,Ian A. York,Efstratios Stratikos +10 more
TL;DR: Cell-based Ag-presentation analysis was consistent with changes in the substrate inhibition constant Ki, supporting that ERAP1 allelic composition may affect Ag processing in vivo and proposing that these phenomena should be taken into account when evaluating the possible link between Ag processing and autoimmunity.
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Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
Efthalia Zervoudi,Emmanuel N. Saridakis,James R. Birtley,Sergey S. Seregin,Emma Reeves,Paraskevi Kokkala,Yasser A. Aldhamen,Andrea Amalfitano,Irene M. Mavridis,Eddie A. James,Dimitris Georgiadis,Efstratios Stratikos +11 more
TL;DR: Antigen processing and presentation assays in HeLa and murine colon carcinoma cells showed that these inhibitors induce increased cell-surface antigen presentation of transfected and endogenous antigens and enhance cytotoxic T-cell responses, indicating that these enzymes primarily destroy epitopes in those systems.
Journal ArticleDOI
Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy
Sergey S. Seregin,Daniel M. Appledorn,Aaron J. Mcbride,Nathaniel J. Schuldt,Yasser A. Aldhamen,Tyler Voss,Junping Wei,Matthew Bujold,William Nance,Sarah Godbehere,Andrea Amalfitano,Andrea Amalfitano +11 more
TL;DR: It is found that a simple pretreatment regimen with Dexamethasone (DEX) can significantly reduce most Ad-induced innate immune responses and transient glucocorticoid pretreatment is a viable approach to reduce rAd-associated acute toxicities that currently limit the use of Ad vectors in systemic clinical applications.