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Irving Phillips
Researcher at Naval Medical Research Center
Publications - 7
Citations - 647
Irving Phillips is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: DNA vaccination & Dengue virus. The author has an hindex of 7, co-authored 7 publications receiving 637 citations.
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Journal ArticleDOI
Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein
Kanakatte Raviprakash,Tadeusz J. Kochel,Daniel Ewing,Monika Simmons,Irving Phillips,Curtis G. Hayes,Kevin R. Porter +6 more
TL;DR: Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.
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A dengue virus serotype-1 DNA vaccine induces virus neutralizing antibodies and provides protection from viral challenge in Aotus monkeys.
Tadeusz J. Kochel,Kanakatte Raviprakash,Curtis G. Hayes,Douglas M. Watts,Kevin L. Russell,Alfonso S. Gozalo,Irving Phillips,Daniel Ewing,Gerald S. Murphy,Kevin R. Porter +9 more
TL;DR: Results demonstrate that DNA immunization is a promising approach for the development of dengue vaccines and that A. nancymae monkeys are suitable for d Dengue vaccine trials.
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Dengue virus type 1 DNA vaccine induces protective immune responses in rhesus macaques.
Kanakatte Raviprakash,Kanakatte Raviprakash,Kevin R. Porter,Tadeuscz J. Kochel,Daniel Ewing,Monica Simmons,Irving Phillips,Gerald S. Murphy,Gerald S. Murphy,Walter R. Weiss,Curtis G. Hayes +10 more
TL;DR: All vaccinated monkeys showed an anamnestic antibody response, indicating that they had established immunological memory, and vaccine-induced antibody had an avidity index similar to that of antibody induced by virus infection; however, no clear correlation was apparent between antibody avidity and virus neutralization titres.
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Protective efficacy of a dengue 2 DNA vaccine in mice and the effect of CpG immuno-stimulatory motifs on antibody responses
K. R. Porter,Tadeusz J. Kochel,S.-J. Wu,Kanakatte Raviprakash,Irving Phillips,Curtis G. Hayes +5 more
TL;DR: These studies illustrate that nucleic acid immunization is a viable approach to developing a DEN vaccine and that immuno-stimulatory CpG DNA motifs can be used to lower the minimum dose required to produce an antibody response.
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The epidemiology of dengue virus infection among urban, jungle, and rural populations in the Amazon Region of Peru
Curtis G. Hayes,Irving Phillips,Johnny D. Callahan,Walter F. Griebenow,Kenneth C. Hyams,Shuenn-Jue Wu,Douglas M. Watts +6 more
TL;DR: The results indicate that dengue virus transmission continues in and around Iquitos and suggest that transmission also occurred prior to the 1990 epidemic.