Isabel Valli

TL;DR: Findings provide evidence that the onset of frank psychosis is preceded by presynaptic dopaminergic dysfunction and further research is needed to determine the specificity of elevated dopamine synthesis capacity to particular psychotic disorders.

TL;DR: In people with prodromal signs of psychosis, there are direct correlations between altered prefrontal cortical function and subcortical dopamine synthesis capacity, consistent with the notion that frontostriatal interactions play a critical role in the pathoetiology of schizophrenia.

TL;DR: This study provides the first evidence that brain glutamate function is perturbed in people with prodromal signs of schizophrenia and that glutamatergic dysfunction is associated with a reduction in gray matter volume in brain regions thought to be critical to the pathogenesis of the disorder.

TL;DR: People with an at-risk mental state display a jumping to conclusions reasoning style, associated with impaired working memory and intolerance of uncertainty, which may underlie a tendency to develop abnormal beliefs and a vulnerability to psychosis.

TL;DR: The results suggest that variations in the rs6265 SNP of the BDNF gene have a significant effect on memory performance, and on both the structure and physiology of the hippocampus, with carriers of the met allele being adversely affected.