Joseph Kambeitz

TL;DR: The locus of the largest dopaminergic abnormality in schizophrenia is presynaptic, which affects dopamine synthesis capacity, baseline synaptic dopamine levels, and dopamine release, and future drug development should focus on the control of presYNaptic dopamine synthesis and release capacity.

TL;DR: In this article, the authors investigated whether its psychotic effects are mediated through an influence on attentional salience processing, and found that chronic use of marijuana may increase the risk of schizophrenia.

TL;DR: Despite the clinical heterogeneity of the schizophrenia phenotype, brain functional and structural alterations differentiate schizophrenic patients from healthy controls with 80% sensitivity and specificity, underline the utility of multivariate pattern recognition approaches for the identification of reliable neuroimaging-based biomarkers.

TL;DR: The relationship between hippocampal glutamate and striatal dopamine systems is altered in people at high risk of psychosis, and the degree to which it is changed may be related to the risk of transition to psychosis.

TL;DR: Structural MRI-based multivariate pattern classification was used to identify and cross-validate a differential diagnostic signature separating patients with first-episode and recurrent stages of schizophrenia from patients with major depression and suggest that neuroanatomical information may provide generalizable diagnostic tools distinguishing schizophrenia from mood disorders early in the course of psychosis.