I
Isabelle Fellay
Researcher at University of Fribourg
Publications - 12
Citations - 1606
Isabelle Fellay is an academic researcher from University of Fribourg. The author has contributed to research in topics: Granzyme & Cytotoxic T cell. The author has an hindex of 9, co-authored 10 publications receiving 1553 citations.
Papers
More filters
Journal ArticleDOI
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
Thierry Rossé,Reynald Olivier,Laurent Monney,Monika Rager,Sébastien Conus,Isabelle Fellay,Burkhard Jansen,Christoph Borner +7 more
TL;DR: It is shown that in cells transiently transfected with bax, Bax localizes to mitochondria and induces the release of cytochrome c, activation of caspase-3, membrane blebbing, nuclear fragmentation, and cell death, indicating that Bcl-2 can interfere with Bax killing downstream of and independently of cy tochrome c release.
Journal ArticleDOI
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2.
Jürg Häcki,Lotti Egger,Laurent Monney,Laurent Monney,Sébastien Conus,Thierry Rossé,Isabelle Fellay,Christoph Borner +7 more
TL;DR: A hitherto unrecognized, apoptotic crosstalk between the ER and mitochondria is uncovered that can be interrupted by ER-based Bcl-2, an agent interfering with N-linked glycosylations in the secretory system.
Journal ArticleDOI
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2
Denis Grandgirard,Erwin Studer,Laurent Monney,Tanja Belser,Isabelle Fellay,Christoph Borner,M. R. Michel +6 more
TL;DR: It is shown that three cell types highly overexpressing functional Bcl‐2 displayed caspase‐3 activation and underwent apoptosis in response to infection with alphaviruses Semliki Forest and Sindbis as efficiently as vector control counterparts.
Journal ArticleDOI
Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain.
Laurent Monney,Isabelle Otter,Reynald Olivier,Ulla Ravn,Hengameh Mirzasaleh,Isabelle Fellay,Guy G. Poirier,Christoph Borner +7 more
TL;DR: Overexpression of Bcl-2 neutralizes an unknown cellular activator of CPP32 to save cells from programmed cell death and shows protection from tumor necrosis factor alpha-induced death.
Journal ArticleDOI
Bcl‐2 is a monomeric protein: prevention of homodimerization by structural constraints
Sébastien Conus,Thomas Kaufmann,Isabelle Fellay,Isabelle Otter,Isabelle Otter,Thierry Rossé,Christoph Borner +6 more
TL;DR: Data indicate that naturally occurring Bcl‐2 does not expose protein domains that mediate homodimerization and therefore most likely acts as a monomer to protect cells from apoptosis.