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Isabelle Galeraud-Denis
Researcher at University of Caen Lower Normandy
Publications - 16
Citations - 1034
Isabelle Galeraud-Denis is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Aromatase & Spermatogenesis. The author has an hindex of 12, co-authored 16 publications receiving 969 citations.
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Analysis and significance of mRNA in human ejaculated sperm from normozoospermic donors: relationship to sperm motility and capacitation
TL;DR: Using discontinuous density gradients, isolated high and low motile sperm from the same semen sample to analyse mRNA profiles could be helpful as a diagnostic tool and prognosis value for fertilization.
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Reproductive system: aromatase and estrogens
Serge Carreau,Sonia Bourguiba,Sophie Lambard,Isabelle Galeraud-Denis,Christelle Genissel,Jérôme Levallet +5 more
TL;DR: The aromatase gene expression and its translation in a fully active protein in rodent germ cells evidence an additional site for estrogen production within the testis, a positive correlation between a fully developed spermatogenesis and a strong immunoreactivity.
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Human immature germ cells and ejaculated spermatozoa contain aromatase and oestrogen receptors.
TL;DR: P450 arom and ER proteins (full-length and variant) in human germ cells are identified and further studies are now required to elucidate the mechanism of action of oestrogens on human male germ cells, in terms of both genomic and 'non-genomic' pathways.
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Aromatase, oestrogens and human male reproduction
TL;DR: A role for aromatase/oestrogens not only during the development and maintenance of spermatogenesis but also in the final maturation of spermatozoa is suggested, even if the role of oestrogens is still a matter of debate.
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Expression of aromatase in human ejaculated spermatozoa: a putative marker of motility.
Sophie Lambard,Isabelle Galeraud-Denis,Hélène Bouraïma,Sonia Bourguiba,Anne Chocat,Serge Carreau +5 more
TL;DR: The data demonstrate the expression of aromatase both in terms of mRNA and protein in each sample of human purified spermatozoa and in addition, the results suggest that arom atase could be concerned with the acquisition of sperm motility.