Sophie Lambard

TL;DR: In the rat testis and bank-vole testis a positive correlation between a fully developed spermatogenesis and a strong immunoreactivity for both P450arom and estrogen receptor β and the recent data obtained from ejaculated human spermatozoa demonstrate the presence of aromatase both in terms of mRNA and protein, and it is suggested that aromat enzyme could be involved in the acquisition of sperm motility.

TL;DR: Using discontinuous density gradients, isolated high and low motile sperm from the same semen sample to analyse mRNA profiles could be helpful as a diagnostic tool and prognosis value for fertilization.

TL;DR: The aromatase gene expression and its translation in a fully active protein in rodent germ cells evidence an additional site for estrogen production within the testis, a positive correlation between a fully developed spermatogenesis and a strong immunoreactivity.

TL;DR: P450 arom and ER proteins (full-length and variant) in human germ cells are identified and further studies are now required to elucidate the mechanism of action of oestrogens on human male germ cells, in terms of both genomic and 'non-genomic' pathways.

TL;DR: It is established that testosterone (T) enhances CYP19 gene expression in Leydig cells and germ cells, and augments the estradiol outputs, and several factors direct the expression of the aromatase gene and it is obvious that not only promoter PII but also promoter PI are concerned.