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Isabelle Pagnier
Researcher at Aix-Marseille University
Publications - 55
Citations - 3918
Isabelle Pagnier is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Giant Virus & Mimivirus. The author has an hindex of 26, co-authored 51 publications receiving 3489 citations. Previous affiliations of Isabelle Pagnier include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Microbial culturomics: paradigm shift in the human gut microbiome study
Jean-Christophe Lagier,Fabrice Armougom,Matthieu Million,Perrine Hugon,Isabelle Pagnier,Catherine Robert,Fadi Bittar,Ghislain Fournous,Gregory Gimenez,Marie Maraninchi,Jean-François Trape,Eugene V. Koonin,B. La Scola,Didier Raoult +13 more
TL;DR: Culturomics complements metagenomics by overcoming the depth bias inherent in metagenomic approaches, and identifies 174 species never described previously in the human gut.
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The Virophage as a Unique Parasite of the Giant Mimivirus
Bernard La Scola,Christelle Desnues,Isabelle Pagnier,Catherine Robert,Lina Barrassi,Ghislain Fournous,Michèle Merchat,Marie Suzan-Monti,Patrick Forterre,Patrick Forterre,Eugene V. Koonin,Didier Raoult +11 more
TL;DR: The Sputnik genome is an 18.343-kilobase circular double-stranded DNA and contains genes that are linked to viruses infecting each of the three domains of life Eukarya, Archaea and Bacteria and is classified as a virophage.
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Current and Past Strategies for Bacterial Culture in Clinical Microbiology
Jean-Christophe Lagier,Sophie Edouard,Isabelle Pagnier,Oleg Mediannikov,Michel Drancourt,Didier Raoult +5 more
TL;DR: The development of axenic media for the culture of Treponema pallidum or Mycobacterium leprae remains an important challenge that the patience and innovations of cultivators will enable them to overcome.
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Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms
Mickaël Boyer,Natalya Yutin,Isabelle Pagnier,Lina Barrassi,Ghislain Fournous,Leon Espinosa,Catherine Robert,Saïd Azza,Siyang Sun,Michael G. Rossmann,Marie Suzan-Monti,Bernard La Scola,Eugene V. Koonin,Didier Raoult +13 more
TL;DR: It is proposed that amoebae are “melting pots” of microbial evolution where diverse forms emerge, including giant viruses with complex gene repertoires of various origins.
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Mimivirus shows dramatic genome reduction after intraamoebal culture
Mickaël Boyer,Saïd Azza,Lina Barrassi,Thomas Klose,Angélique Campocasso,Isabelle Pagnier,Ghislain Fournous,Audrey Borg,Catherine Robert,Xinzheng Zhang,Christelle Desnues,Bernard Henrissat,Michael G. Rossmann,Bernard La Scola,Didier Raoult +14 more
TL;DR: The Mimivirus transition from a sympatric to an allopatric lifestyle was associated with a stepwise genome reduction and the production of a predominantly bald virophage resistant strain and the new axenic ecosystem allowed the allop atric Mimiv virus to lose unnecessary genes that might be involved in the control of competitors.