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Isabelle Portal
Researcher at Aix-Marseille University
Publications - 32
Citations - 1764
Isabelle Portal is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Hepatitis C virus & Hepatitis C. The author has an hindex of 17, co-authored 30 publications receiving 1580 citations.
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Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study
Fabrice Carrat,Hélène Fontaine,Céline Dorival,Mélanie Simony,Alpha Diallo,Christophe Hézode,Victor de Ledinghen,Dominique Larrey,Georges Haour,Jean-Pierre Bronowicki,Fabien Zoulim,Tarik Asselah,Patrick Marcellin,Dominique Thabut,Vincent Leroy,Albert Tran,François Habersetzer,Didier Samuel,Dominique Guyader,Olivier Chazouillères,Philippe Mathurin,Sophie Metivier,Laurent Alric,Ghassan Riachi,Jérôme Gournay,Armand Abergel,Paul Calès,Nathalie Ganne,Véronique Loustaud-Ratti,Louis d’Alteroche,Xavier Causse,Claire Geist,Anne Minello,Isabelle Rosa,Moana Gelu-Simeon,Isabelle Portal,François Raffi,Marc Bourlière,Stanislas Pol +38 more
TL;DR: Treatment with direct-acting antivirals is associated with reduced risk for mortality and hepatocellular carcinoma and should be considered in all patients with chronic HCV infection.
Journal ArticleDOI
Effectiveness of Telaprevir or Boceprevir in Treatment-Experienced Patients With HCV Genotype 1 Infection and Cirrhosis
Christophe Hézode,Hélène Fontaine,Céline Dorival,Fabien Zoulim,Dominique Larrey,Valérie Canva,Victor de Lédinghen,Thierry Poynard,Didier Samuel,Marc Bourlière,Laurent Alric,Jean Jacques Raabe,Jean-Pierre Zarski,Patrick Marcellin,Ghassan Riachi,Pierre Bernard,Veronique Loustaud Ratti,Olivier Chazouillères,Armand Abergel,Dominique Guyader,Sophie Metivier,Albert Tran,Vincent Di Martino,Xavier Causse,Thong Dao,Damien Lucidarme,Isabelle Portal,Patrice Cacoub,Jérôme Gournay,Veronique Grando–Lemaire,Patrick Hillon,Pierre Attali,T. Fontanges,Isabelle Rosa,Ventzislava Petrov–Sanchez,Yoann Barthe,Jean-Michel Pawlotsky,Stanislas Pol,Fabrice Carrat,Jean-Pierre Bronowicki +39 more
TL;DR: The Compassionate Use of Protease Inhibitors in Viral C Cirrhosis (COCIR) study as mentioned in this paper investigated the effectiveness of the protease inhibitors peginterferon and ribavirin in treatment-experienced patients with hepatitis C virus (HCV) genotype 1 infection and cirrhosis.
Journal ArticleDOI
Independent Prospective Multicenter Validation of Biochemical Markers (Fibrotest-Actitest) for the Prediction of Liver Fibrosis and Activity in Patients with Chronic Hepatitis C: The Fibropaca Study
Philippe Halfon,Marc Bourlière,R. Deydier,Danielle Botta-Fridlund,Christophe Renou,Albert Tran,Isabelle Portal,Isabelle Allemand,Jean Jacques Bertrand,Alessandra Rosenthal-Allieri,Michel Rotily,Christophe Sattonet,Thierry Benderitter,Marie Christine Saint Paul,Henry Pierre Bonnot,Guillaume Penaranda,Claude Degott,Denis Ouzan +17 more
TL;DR: This prospective independent and multicenter study confirms the diagnostic value ofFT and AT found in the princeps study and suggests that FT and AT can be an alternative to biopsy in most patients with chronic HCV.
Journal ArticleDOI
Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus.
Philippe Halfon,Marc Bourlière,Guillaume Penaranda,R. Deydier,Christophe Renou,Danielle Botta-Fridlund,Albert Tran,Isabelle Portal,Isabelle Allemand,Alessandra Rosenthal-Allieri,Denis Ouzan +10 more
TL;DR: It was shown that serum hyaluronic acid (HA) level increases with the development for liver fibrosis, and accurate HA level cut-offs were defined for predicting significant fibrosis and/or cirrhosis.
Journal ArticleDOI
Changing of hepatitis C virus genotype patterns in France at the beginning of the third millenium: The GEMHEP GenoCII Study.
Christopher Payan,Françoise Roudot-Thoraval,Patrick Marcellin,N. Bled,Gilles Duverlie,Isabelle Fouchard-Hubert,Pascale Trimoulet,P. Couzigou,D. Cointe,C. Chaput,Cécile Henquell,Armand Abergel,Jean-Michel Pawlotsky,Christophe Hézode,M. Coudé,A. Blanchi,Sophie Alain,Véronique Loustaud-Ratti,P. Chevallier,Christian Trepo,V. Gerolami,Isabelle Portal,Philippe Halfon,Marc Bourlière,Marc Bogard,E. Plouvier,Catherine Laffont,G. Agius,C. Silvain,V. Brodard,G. Thiefin,Claudine Buffet-Janvresse,Ghassan Riachi,Florence Grattard,Thomas Bourlet,Françoise Stoll-Keller,M. Doffoel,Jacques Izopet,K. Barange,Michelle Martinot-Peignoux,Michel Branger,Arielle R. Rosenberg,P. Sogni,Marie-Laure Chaix,Stanislas Pol,V. Thibault,P. Opolon,A. Charrois,Lawrence Serfaty,B. Fouqueray,Jean-Didier Grangé,J.-J. Lefrère,Françoise Lunel-Fabiani +52 more
TL;DR: A changing pattern of HCV genotypes in France is shown, with i.v. drug abuse as the major risk factor, an increase of genotype 4, and to a lesser extent 1a and 5, and a decrease of genotypes 1b and 2.