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Claude Degott
Researcher at French Institute of Health and Medical Research
Publications - 319
Citations - 24823
Claude Degott is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis & Cirrhosis. The author has an hindex of 87, co-authored 319 publications receiving 24127 citations.
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Journal ArticleDOI
Organ-Specific Disease Provoked by Systemic Autoimmunity
Valerie Kouskoff,Anne-Sophie Korganow,Veronique Duchatelle,Claude Degott,Christophe Benoist,Diane Mathis +5 more
TL;DR: A spontaneous mouse model of RA is described, generated fortuitously by crossing a T cell receptor (TCR) transgenic line with the NOD strain, and it is suggested that human RA develops by an analogous mechanism.
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Pegylated interferon alfa-2b vs standard interferon alfa-2b, plus ribavirin, for chronic hepatitis C in HIV-infected patients: a randomized controlled trial.
Fabrice Carrat,Firouzé Bani-Sadr,Stanislas Pol,Eric Rosenthal,Françoise Lunel-Fabiani,Asmae Benzekri,Patrice Morand,Cécile Goujard,Gilles Pialoux,Lionel Piroth,Dominique Salmon-Ceron,Claude Degott,Patrice Cacoub,Christian Perronne +13 more
TL;DR: In this article, the safety and efficacy of the combination of peginterferon alfa-2b and ribavirin was evaluated in HCV-infected patients.
Journal ArticleDOI
Arthritis Critically Dependent on Innate Immune System Players
Hong Ji,Koichiro Ohmura,Koichiro Ohmura,Umar Mahmood,David M. Lee,Frans M. A. Hofhuis,Susan A. Boackle,Kazue Takahashi,V. Michael Holers,Mark Walport,Craig Gerard,Alan Ezekowitz,Michael C. Carroll,Michael B. Brenner,Ralph Weissleder,J. Sjef Verbeek,Veronique Duchatelle,Claude Degott,Christophe Benoist,Christophe Benoist,Christophe Benoist,Diane Mathis,Diane Mathis,Diane Mathis +23 more
TL;DR: It is suggested that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response.
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From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
Anne-Sophie Korganow,Hong Ji,Sara Mangialaio,Veronique Duchatelle,Roberta Pelanda,Thierry Martin,Claude Degott,Hitoshi Kikutani,Klaus Rajewsky,Jean-Louis Pasquali,Christophe Benoist,Diane Mathis +11 more
TL;DR: The role of B cells as the secretion of arthritogenic immunoglobulins is identified in rheumatoid arthritis and it is suggested that a similar scenario may unfold in some other arthritis models and in human patients, beginning with pervasive T cell autoreactivity and ending in immunoglobeulin-provoked joint destruction.
Journal ArticleDOI
Long-Term Histologic Improvement and Loss of Detectable Intrahepatic HCV RNA in Patients with Chronic Hepatitis C and Sustained Response to Interferon-α Therapy
Patrick Marcellin,Nathalie Boyer,Anne Gervais,M. Martinot,Michèle Pouteau,Corinne Castelnau,Afef Kilani,Jorge A. Areias,Anne Auperin,Jean Pierre Benhamou,Claude Degott,Serge Erlinger +11 more
TL;DR: The long-term biochemical, virologic, and histologic outcomes of 80 patients with chronic hepatitis C who had a sustained response during the 6 months after interferon- therapy are assessed.