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Issam Hanna
Researcher at École Polytechnique
Publications - 95
Citations - 1145
Issam Hanna is an academic researcher from École Polytechnique. The author has contributed to research in topics: Ring (chemistry) & Bicyclic molecule. The author has an hindex of 20, co-authored 95 publications receiving 1129 citations. Previous affiliations of Issam Hanna include École Normale Supérieure & University of New Orleans.
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Formal synthesis of (+/-)-guanacastepene A: a tandem ring-closing metathesis approach.
TL;DR: A concise route to a key intermediate in the total synthesis of guanacastepene A is described, which includes the simultaneous construction of the seven- and six-membered rings using a tandem ring-closing metathesis and a stereoselective introduction of the oxygenated function at the C5 position.
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Gold(I)-catalyzed cycloisomerization of 1,7- and 1,8-enynes: application to the synthesis of a new allocolchicinoid.
TL;DR: Gold(I)-catalyzed cycloisomerization of 1,7- and 1,8-enyne propargylic acetates afforded cyclopropyl derivatives containing seven- and eight-membered rings, respectively.
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From galactose to highly functionalized seven- and eight-membered carbocyclic rings by ring-closing metathesis.
Issam Hanna,Louis Ricard +1 more
TL;DR: A short synthesis of highly functionalized seven- and eight-membered carbocyclic rings from galactose derivatives has been achieved using zinc-mediated reductive ring opening and a subsequent ring-closing olefin metathesis using Grubbs' ruthenium catalyst.
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Synthesis of a highly functionalized tricyclic ring system related to guanacastepene via a tandem ring-closing metathesis reaction
TL;DR: A new approach to a highly functionalized 5,7,6-tricyclic core structure of guanacastepene has been developed using the tandem ring-closing metathesis reaction of dienynes as the key step.
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Synthesis of allocolchicines using sequential ring-closing enyne metathesis-Diels-Alder reactions.
TL;DR: New allocolchinoids having functionality in the C ring at position C10 or C11 have been synthesized using the enyne ring-closing metathesis (RCM) reaction for construction of the seven-membered ring and a Diels-Alder-aromatization sequence for the elaboration of the aromatic ring C.