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István Dányi
Researcher at Laboratory of Molecular Biology
Publications - 4
Citations - 290
István Dányi is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Translation reinitiation & Eukaryotic Small Ribosomal Subunit. The author has an hindex of 4, co-authored 4 publications receiving 270 citations. Previous affiliations of István Dányi include Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning
Lucie Cuchalová,Tomáš Kouba,Anna Herrmannová,István Dányi,Wen-Ling Chiu,Leoš Shivaya Valášek +5 more
TL;DR: Functional characterization of two essential Saccharomyces cerevisiae eIF3 subunits, g/Tif35 and i/ Tif34, previously suggested to be dispensable for formation of the 48S preinitiation complexes (PICs) in vitro are described.
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Translation reinitiation relies on the interaction between eIF3a/TIF32 and progressively folded cis-acting mRNA elements preceding short uORFs.
Vanda Munzarová,Josef Pánek,Stanislava Gunišová,István Dányi,Béla Szamecz,Leoš Shivaya Valášek +5 more
TL;DR: It is demonstrated that the 5′ enhancer's stimulatory activity is strictly dependent on and thus follows the 3′ enhancers' activity, and for the first time a model of events required for efficient post-termination resumption of scanning is proposed.
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Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly
Anna Herrmannová,Dalia Daujotytė,Ji-Chun Yang,Lucie Cuchalová,Fabrice Gorrec,Susan Wagner,István Dányi,Peter J. Lukavsky,Leoš Shivaya Valášek +8 more
TL;DR: It is concluded that the C-terminus of eIF3b/PRT1 orchestrates co-operative recruitment of eif3i/TIF34 and eIF 3g/Tif35 to the 40S subunit for a stable and proper assembly of 48S pre-initiation complexes necessary for stringent AUG recognition on mRNAs.
Journal ArticleDOI
Small Ribosomal Protein RPS0 Stimulates Translation Initiation by Mediating 40S-Binding of eIF3 via Its Direct Contact with the eIF3a/TIF32 Subunit
Tomáš Kouba,István Dányi,Stanislava Gunišová,Vanda Munzarová,Vladislava Vlčková,Lucie Cuchalová,Andreas Neueder,Philipp Milkereit,Leoš Shivaya Valášek +8 more
TL;DR: It is shown that the interaction between the flexible RPS0A-CTT and the residues 200–400 of the a/TIF32-NTD significantly stimulates attachment of eIF3 and its associated eIFs to small ribosomal subunits in vivo.