P
Philipp Milkereit
Researcher at University of Regensburg
Publications - 54
Citations - 2646
Philipp Milkereit is an academic researcher from University of Regensburg. The author has contributed to research in topics: Ribosomal protein & Ribosomal RNA. The author has an hindex of 25, co-authored 46 publications receiving 2391 citations. Previous affiliations of Philipp Milkereit include Heidelberg University & University of California, Santa Cruz.
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Journal ArticleDOI
Roles of Eukaryotic Ribosomal Proteins in Maturation and Transport of Pre-18S rRNA and Ribosome Function
Sébastien Ferreira-Cerca,Sébastien Ferreira-Cerca,Gisela Pöll,Pierre-Emmanuel Gleizes,Herbert Tschochner,Philipp Milkereit +5 more
TL;DR: Comparative analysis of dynamic and steady-state maturation assays revealed that several r-proteins are required for efficient nuclear export of pre-18S rRNA, suggesting that they form an interaction platform with the export machinery.
Journal ArticleDOI
Nucleotide-induced Conformational Changes in the ATPase and Substrate Binding Domains of the DnaK Chaperone Provide Evidence for Interdomain Communication
Alexander Buchberger,Holger Theyssen,Hartwig Schröder,John S. McCarty,Giuseppe Virgallita,Philipp Milkereit,Jochen Reinstein,Bernd Bukau +7 more
TL;DR: Fluorescence analysis of the N-terminally located single tryptophan residue of DnaK revealed that the known ATP-induced alteration of the emission spectrum, proposed to result directly from conformational changes in the ATPase domain, requires the presence of the C-terminal domain and therefore mainly results from altered domain interaction.
Journal ArticleDOI
Maturation and Intranuclear Transport of Pre-Ribosomes Requires Noc Proteins
Philipp Milkereit,Olivier Gadal,Alexander Podtelejnikov,Stéphanie Trumtel,Nicole Gas,Elisabeth Petfalski,David Tollervey,Mathias Mann,Ed Hurt,Herbert Tschochner +9 more
TL;DR: It is proposed that the dynamic interaction of Noc proteins is crucial for intranuclear movement of ribosomal precursor particles, and, thereby represent a prerequisite for proper maturation.
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The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3
Gérald Peyroche,Philipp Milkereit,Nicolas Bischler,Herbert Tschochner,Patrick Schultz,André Sentenac,Christophe Carles,Michel Riva +7 more
TL;DR: The results suggest that Rrn3 plays a central role in Pol I recruitment to rDNA promoters by bridging the enzyme to the core factor.
Journal ArticleDOI
Analysis of the in vivo assembly pathway of eukaryotic 40S ribosomal proteins.
Sébastien Ferreira-Cerca,Gisela Pöll,Holger Kühn,Andreas Neueder,Steffen Jakob,Herbert Tschochner,Philipp Milkereit +6 more
TL;DR: The results show that key aspects of the assembly of eukaryotic r-proteins into distinct structural parts of the SSU are similar to the in vitro assembly pathway of their prokaryotic counterparts.