Itsuro Sobue

TL;DR: There was no significant difference in incidence of the major clinical manifestations between the two groups with and without myeloma, and they had a common characteristic histologic finding of the lymph node resembling that of Castleman's disease.

TL;DR: A familial group of patients with paralysis agitans of early onset characterized by marked diurnal fluctuation of symptoms, which has only been reported by Nasu, Aoyama and Morisada2 and by the authors of this paper.

TL;DR: Clinical features consisted of juvenile onset, male preponderance, unique distribution of the muscular atrophy in the hand and forearm, tendon reflexes hypoactive in most cases but hyperactive in some, no definite sensory disturbances, no involvement of the cranial nerves, and autonomic nerve disorders in the affected region.

TL;DR: From the serial determination of these substances, they would be better markers for damage of the nervous system than cell counts and total protein in CSF for the active injury for the nervous tissues.

TL;DR: If the demonstrated deposition of metals, particularly calcium and aluminum, in central nervous system tissues of Guamanians with these two conditions is a cause of the diseases and of the early appearance of neurofibrillary tangles in neurons, the accumulation has apparently occurred long before onset of symptoms, and detectable abnormalities of calcium and vitamin D metabolism may already have been corrected.