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Itzhak Fischer
Researcher at Drexel University
Publications - 190
Citations - 11562
Itzhak Fischer is an academic researcher from Drexel University. The author has contributed to research in topics: Transplantation & Spinal cord. The author has an hindex of 60, co-authored 181 publications receiving 10909 citations. Previous affiliations of Itzhak Fischer include King's College London & Temple University.
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In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.
TL;DR: The data suggested that the hMSCs may have been differentiated into early progenitors of neural cells in vitro under conditions that increase the intracellular level of cAMP.
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Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function
Yi Liu,Duckhyun Kim,B. Timothy Himes,B. Timothy Himes,S. Y. Chow,Timothy J Schallert,Marion Murray,Alan Tessler,Alan Tessler,Itzhak Fischer +9 more
TL;DR: Transplants of fibroblasts genetically engineered to produce brain-derived neurotrophic factor (BDNF) would promote rubrospinal tract (RST) regeneration in adult rats showed significant recovery of forelimb usage, which was abolished by a second lesion that transected the regenerated axons.
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Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype.
Birgit Neuhuber,Gianluca Gallo,Linda Howard,Lisa Kostura,Alastair Morgan Mackay,Itzhak Fischer +5 more
TL;DR: The ability of cultured rat MSC to undergo in vitro osteogenesis, chondrogenesis, and adipogenesis is confirmed, demonstrating differentiation of these cells to three mesenchymal cell fates, and changes in morphology upon addition of the chemical induction medium were caused by rapid disruption of the actin cytoskeleton.
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Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations.
Birgit Neuhuber,B. Timothy Himes,B. Timothy Himes,Jed S. Shumsky,Gianluca Gallo,Itzhak Fischer +5 more
TL;DR: In this paper, the authors found that axon growth through the graft site varied considerably between groups of animals treated with different MSC lots, suggesting that efficacy may be donor-dependent.
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Tau Is Enriched on Dynamic Microtubules in the Distal Region of Growing Axons
TL;DR: It is proposed that tau in growing axons has functions other than promoting microtubule assembly and stability and that key sites for these functions are the distal axon and growth cone.