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Iván Kanizsai
Researcher at University of Szeged
Publications - 47
Citations - 597
Iván Kanizsai is an academic researcher from University of Szeged. The author has contributed to research in topics: Apoptosis & Cytotoxic T cell. The author has an hindex of 13, co-authored 45 publications receiving 501 citations. Previous affiliations of Iván Kanizsai include Ghent University.
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Synthesis of bi- and tricyclic β-lactam libraries in aqueous medium
TL;DR: In this paper, the Ugi four-centre three-component reaction (U-4C-3CR) was used to construct β-lactam libraries in aqueous medium.
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The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.
László Hackler,Béla Ózsvári,Márió Gyuris,Péter Sipos,Gabriella Fábián,Eszter Molnár,Annamária Marton,Nóra Faragó,József Mihály,Lajos Nagy,Tibor Szénási,Andrea Diron,Árpád Párducz,Iván Kanizsai,László G. Puskás +14 more
TL;DR: In an in vivo orthotopic glioma model, C-150 significantly increased the median survival of treated nude rats compared to control animals, and its preliminary in vivo efficacy would render this curcumin analogue as a potent clinical candidate against glioblastoma.
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Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells
László G. Puskás,Liliána Z. Fehér,Csaba Vizler,Ferhan Ayaydin,Erzsébet Rásó,Eszter Molnár,István Magyary,Iván Kanizsai,Márió Gyuris,Ramóna Madácsi,Gabriella Fábián,Klaudia Farkas,Péter Hegyi,Ferenc Baska,Béla Ózsvári,Klára Kitajka +15 more
TL;DR: Because of the anticancer, anti-angiogenic action and the wide range of applicability of the immunomodulatory drugs, including thalidomide analogs, lipid droplet-binding members of this family could represent a new class of agents by affecting ER-membrane integrity and perturbations of ER homeostasis.
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Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells
Gábor J. Szebeni,Árpád Balázs,Ildikó Madarász,Gábor Pócz,Ferhan Ayaydin,Iván Kanizsai,Roberta Fajka-Boja,Róbert Alföldi,László Hackler,László G. Puskás +9 more
TL;DR: Achiral curcumin analogs, C509, C521 and C524 possessed superior, 40-times more potent cytotoxic activity compared to natural dihydroxy-dimetoxycurcumin in PANC-1 cells, proving to cause phosphatidylserine exposure as an early sign of apoptosis.
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A cell-microelectronic sensing technique for the screening of cytoprotective compounds
Béla Ózsvári,László G. Puskás,Lajos Nagy,Iván Kanizsai,Márió Gyuris,Ramóna Madácsi,Liliána Z. Fehér,Domokos Gero,Csaba Szabó,Csaba Szabó +9 more
TL;DR: A cell-microelectronic sensing technique (RT-CES), which measures changes in the impedance of individual microelectronic wells that correlates linearly with cell index, thereby allowing the continuous determination of cell viability during oxidative stress, is applied.