Ivanka Tsakovska

TL;DR: The potential use of phenothiazine-type MDR modulators as a model system in the further investigations of the MDR phenomenon is outlined and results point to MDR modulation byphenothiazines and related compounds as a complex process in which more than one mechanism are certainly involved.

TL;DR: The combined in vitro/in silico approach can be used for the preliminary evaluation of GIA and to guide further laboratory experiments on pharmacokinetic characterization of bioactive compounds, including natural products.

TL;DR: The PPARγ activation helix does not undergo dramatic conformational changes, as seen in other nuclear receptors, but rather perturbations that occur through a significant ligand-induced reshaping of the lig and-receptor and the receptor-coactivator binding pockets.

TL;DR: This chapter provides an overview of the molecular modeling approaches applied to ligand-ER interactions, and some critical issues are analyzed based on recently published models where these approaches are applied.