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Ivica Granic
Researcher at University of Groningen
Publications - 12
Citations - 545
Ivica Granic is an academic researcher from University of Groningen. The author has contributed to research in topics: Excitotoxicity & Cholinergic neuron. The author has an hindex of 9, co-authored 12 publications receiving 486 citations. Previous affiliations of Ivica Granic include Radboud University Nijmegen.
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Inflammation and NF-kappa B in Alzheimer's Disease and Diabetes
TL;DR: The authors reviewed the literature on how inflammation and the inducible nuclear factor NF-kappaB might be involved in both diabetes mellitus and Alzheimer's disease and whether these factors can link both diseases.
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The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine.
TL;DR: In this study the neuroprotective effect of memantine on the forebrain cholinergic neurons against Aβ42 oligomers-induced toxicity was studied in an in vivo rat dementia model and it was found that memantine rescued the neocorticalcholinergic fibers originating from the basal forebrain dendritic neurons.
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TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappa B-dependent up-regulation of K(Ca)2.2 channels
Amalia M. Dolga,Ivica Granic,Thomas Blank,Hans-Guenther Knaus,Joachim Spiess,Paul G.M. Luiten,Ulrich L. M. Eisel,Ingrid M. Nijholt +7 more
TL;DR: Treatment of primary cortical neurons with TNF‐α leads to increased KCa2.2 channel expression which renders neurons more resistant to excitotoxic cell death, resulting in neuroprotection against neuronal overstimulation.
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Calpain inhibition prevents amyloid-beta-induced neurodegeneration and associated behavioral dysfunction in rats.
Ivica Granic,Csaba Nyakas,Csaba Nyakas,Paul G.M. Luiten,Ulrich L. M. Eisel,László G. Halmy,Gerhard Gross,Hans Schoemaker,Achim Möller,Volker Nimmrich +9 more
TL;DR: It is concluded that inhibition of calpains may represent a valuable strategy for the prevention of Abeta oligomer-induced neuronal decline and associated cognitive deterioration.
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Chronic partial sleep deprivation reduces brain sensitivity to glutamate N‐methyl‐d‐aspartate receptor‐mediated neurotoxicity
TL;DR: The data suggest that chronic SR may constitute a mild threat to the brain that does not lead to neurodegeneration by itself but prepares the brain for subsequent neurotoxic challenges, and suggest that, if anything, SR reduces the sensitivity to a subsequent excitotoxic insult.