J
J. Alastair Gracie
Researcher at University of Glasgow
Publications - 26
Citations - 3148
J. Alastair Gracie is an academic researcher from University of Glasgow. The author has contributed to research in topics: Cytokine & Proinflammatory cytokine. The author has an hindex of 20, co-authored 26 publications receiving 3019 citations. Previous affiliations of J. Alastair Gracie include Life Sciences Institute & Glasgow Royal Infirmary.
Papers
More filters
Journal ArticleDOI
A proinflammatory role for IL-18 in rheumatoid arthritis.
J. Alastair Gracie,Rosalyn J. Forsey,Woon Ling Chan,A. Gilmour,Bernard P. Leung,Morag R. Greer,Kristy Kennedy,Robert W. Carter,Xiao-Qing Wei,Damo Xu,Max Field,Alan Foulis,Foo Y. Liew,Iain B. McInnes +13 more
TL;DR: IL-18 administration to collagen/incomplete Freund's adjuvant-immunized DBA/1 mice facilitated the development of an erosive, inflammatory arthritis, suggesting that IL-18 can be proinflammatory in vivo.
Journal ArticleDOI
A Novel Anti-Inflammatory Role for Simvastatin in Inflammatory Arthritis
Bernard P. Leung,Naveed Sattar,Anne Crilly,Morag Prach,D McCarey,Helen Payne,Rajan Madhok,Carol Campbell,J. Alastair Gracie,Foo Y. Liew,Iain B. McInnes +10 more
TL;DR: It is reported that simvastatin markedly inhibited not only developing but also clinically evident collagen-induced arthritis in doses that were unable to significantly alter cholesterol concentrations in vivo.
Journal ArticleDOI
Targeting interleukin‐15 in patients with rheumatoid arthritis: A proof‐of‐concept study
Bo Baslund,Niels Tvede,Bente Danneskiold-Samsøe,Per Larsson,Gabriel S. Panayi,Joergen Petersen,Lars Jelstrup Petersen,Frank J. Beurskens,Janine Schuurman,Jan G. J. van de Winkel,Paul W. H. I. Parren,J. Alastair Gracie,Sarah L. Jongbloed,Foo Y. Liew,Iain B. McInnes +14 more
TL;DR: Clinical data suggest for the first time that IL-15 could represent a novel therapeutic target in RA and HuMax-IL15 was well tolerated clinically, with no significant effects on T lymphocyte subset and natural killer cell numbers.
Journal ArticleDOI
A Role for IL-18 in Neutrophil Activation
Bernard P. Leung,Shauna Culshaw,J. Alastair Gracie,David Hunter,Claudio Canetti,Carol Campbell,Fernando Q. Cunha,Foo Y. Liew,Iain B. McInnes +8 more
TL;DR: A novel role for IL-18 in activating neutrophils and thereby promoting early innate immune responses is defined and is defined by the capacity to release cytokine and chemokine in neutrophil derived from rheumatoid arthritis synovial fluid.
Journal ArticleDOI
A Novel Therapeutic Approach Targeting Articular Inflammation Using the Filarial Nematode-Derived Phosphorylcholine-Containing Glycoprotein ES-62
Iain B. McInnes,Bernard P. Leung,Margaret M. Harnett,J. Alastair Gracie,Foo Y. Liew,William Harnett +5 more
TL;DR: Proof of concept is provided that parasite-derived immunomodulatory strategies offer a novel therapeutic opportunity in inflammatory arthritis by suppression of collagen-induced arthritis severity and progression when administration was delayed until after clinically evident disease onset.