J. Ann McCay

TL;DR: Genistein enhanced host resistance as evaluated in the B16F10 tumor model, which may be related to the increases in the activities of cytotoxic T cells and NK cells.

TL;DR: The observation that TCDD could directly suppress the antibody response by spleen cells from DBA/2 mice, at concentrations comparable to those required to suppress the B6C3F1 mice, suggested that the effect on the B-lymphocyte was atypical of the profile of activity (i.e., dependence on the Ah locus) previously reported to characterize the effects of dioxin in other systems.

TL;DR: Treatment with AAGM1 did not appear to perturb the function of other immune cells, based on results of the plaque assay, the mixed lymphocyte response, the cytotoxic T lymphocyteresponse, the reticuloendothelial system clearance of sRBC assay, and the Streptococcus pneumoniae host resistance assay.

TL;DR: D5 exposure did not modulate humoral immunity, while the internal control, CYP, produced the expected suppression of the AFC response and no observed effect level for systemic toxicity was observed.

TL;DR: Dietary exposure to NP can increase splenic natural killer cell activity and splenocyte subpopulation numbers in the F(1) generation rats, without similar changes to theF(0) generation.